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β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.

Identificadores del recurso

Gekas C, D'Altri T, Aligué R, González J, Espinosa L, Bigas A. β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1. Leukemia. 2016 Oct;30(10):2002-2010. doi: 10.1038/leu.2016.106

0887-6924

http://hdl.handle.net/10230/27424

http://dx.doi.org/10.1038/leu.2016.106

Procedència

(e-Repositori: Repositori digital de la UPF)

Fitxa

Títol:: β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.
Tema:: Leucèmia aguda -- Aspectes genètics
Descripció:: Notch activation is instrumental in the development of most T-cell acute lymphoblastic leukemia (T-ALL) cases, yet Notch mutations alone are not sufficient to recapitulate the full human disease in animal models. We here found that Notch1 activation at the fetal liver (FL) stage expanded the hematopoietic progenitor population and conferred it transplantable leukemic-initiating capacity. However, leukemogenesis and leukemic-initiating cell capacity induced by Notch1 was critically dependent on the levels of β-Catenin in both FL and adult bone marrow contexts. In addition, inhibition of β-Catenin compromised survival and proliferation of human T-ALL cell lines carrying activated Notch1. By transcriptome analyses, we identified the MYC pathway as a crucial element downstream of β-Catenin in these T-ALL cells and demonstrate that the MYC 3' enhancer required β-Catenin and Notch1 recruitment to induce transcription. Finally, PKF115-584 treatment prevented and partially reverted leukemogenesis induced by active Notch1.; This research was funded by the Worldwide Cancer Research (formerly AICR, 13-0064), Fundación AECC (Cancer infantil), Ministerio de Economía y Competitividad (SAF2013-40922-R), Red Temática de Investigación Cooperativa en Cáncer (RD12/0036/0054), Agència de Gestió d’Ajuds Universitaris i de Recerca (AGAUR) (2014SGR-124) to AB
Idioma:: English
Relació:: Leukemia. 2016 Oct;30(10):2002-10
Autor/Productor:: Gekas, Christos; Teresa, D'Altri 1984-; Aligué, Rosa; González, Jessica; Espinosa Blay, Lluís; Bigas Salvans, Anna
Editor:: Nature Publishing Group
Drets:: © Nature Publishing Group. http://dx.doi.org/10.1038/leu.2016.106; info:eu-repo/semantics/openAccess
Data:: 2016
Tipo de recurso:: info:eu-repo/semantics/article; info:eu-repo/semantics/acceptedVersion
Format:: application/pdf

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