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<field name="value">30704070</field>
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<field name="value">Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulating lipid metabolism and cytokine response is attenuated in overweight subjects and shows high inter-individual variability. This suggests that obesity may be exerting a synergistic effect with genetic background disturbing the anti-inflammatory potential of omega-3 long-chain polyunsaturated fatty acids (PUFA). In the present work, a genetic score aiming to explore the risk associated to low grade inflammation and obesity (LGI-Ob) has been elaborated and assessed as a tool to contribute to discern population at risk for metabolic syndrome. Pro-inflammatory gene expression and cytokine production as a response to omega-3 were associated with LGI-Ob score; and lower anti-inflammatory effect of PUFA was observed in subjects with a high genetic score. Furthermore, overweight/obese individuals showed positive correlation of both plasma C-Reactive Protein and triglyceride/HDLc-index with LGI-Ob; and high LGI-Ob score was associated with greater hypertension (p = 0.047), Type 2 diabetes (p = 0.026), and metabolic risk (p = 0.021). The study shows that genetic variation can influence inflammation and omega-3 response, and that the LGI-Ob score could be a useful tool to classify subjects at inflammatory risk and more prone to suffer metabolic syndrome and associated metabolic disturbances.</field>
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<field name="value">S.G. is supported by a PhD fellowship (FPI/1680/2014) of the Conselleria d'Educacio, Cultura i Universitats, del Govern de les Illes Balears, Fondo Social Europeo de la Union Europea. M.C. has been supported by a PhD fellowship (DI-14-06569) of the Ministerio de Economia y Competitividad. This work was supported by the Spanish Government: INTERBIOBES-AGL2015-67019-P (AEI, MINECO/FEDER, EU). The Laboratory of Molecular Biology, Nutrition and Biotechnology is a member of the European Research Network of Excellence NuGO (The European Nutrigenomics Organisation, EU Contract: FOOD-CT-2004-506360 NUGO).</field>
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<field name="value">eng</field>
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<field name="value">MDPI</field>
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<field name="value">Attribution 4.0 International</field>
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<field name="value">http://creativecommons.org/licenses/by/4.0/</field>
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<field name="value">open access</field>
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<field name="value">Metabolic Syndrome</field>
<field name="authority">D024821</field>
<field name="confidence">500</field>
<field name="value">Genetic Predisposition to Disease</field>
<field name="authority">D020022</field>
<field name="confidence">500</field>
<field name="value">Genotype</field>
<field name="authority">D005838</field>
<field name="confidence">500</field>
<field name="value">Young Adult</field>
<field name="authority">D055815</field>
<field name="confidence">500</field>
<field name="value">Adult</field>
<field name="authority">D000328</field>
<field name="confidence">500</field>
<field name="value">Gene Expression Regulation</field>
<field name="authority">D005786</field>
<field name="confidence">500</field>
<field name="value">Humans</field>
<field name="authority">D006801</field>
<field name="confidence">500</field>
<field name="value">Inflammation</field>
<field name="authority">D007249</field>
<field name="confidence">500</field>
<field name="value">Anti-Inflammatory Agents</field>
<field name="authority">D000893</field>
<field name="confidence">500</field>
<field name="value">Obesity</field>
<field name="authority">D009765</field>
<field name="confidence">500</field>
<field name="value">Male</field>
<field name="authority">D008297</field>
<field name="confidence">500</field>
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<field name="authority">D015415</field>
<field name="confidence">500</field>
<field name="value">Eicosapentaenoic Acid</field>
<field name="authority">D015118</field>
<field name="confidence">500</field>
<field name="value">Docosahexaenoic Acids</field>
<field name="authority">D004281</field>
<field name="confidence">500</field>
<field name="value">Female</field>
<field name="authority">D005260</field>
<field name="confidence">500</field>
<field name="value">Risk Factors</field>
<field name="authority">D012307</field>
<field name="confidence">500</field>
<field name="value">Odds Ratio</field>
<field name="authority">D016017</field>
<field name="confidence">500</field>
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<element name="*">
<field name="value">Oportunidad Relativa</field>
<field name="authority">DECSD016017</field>
<field name="confidence">500</field>
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<field name="authority">DECSD015118</field>
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<field name="value">Síndrome Metabólico</field>
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<field name="value">Ácidos Docosahexaenoicos</field>
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<field name="value">Predisposición Genética a la Enfermedad</field>
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<field name="value">Femenino</field>
<field name="authority">DECSD005260</field>
<field name="confidence">500</field>
<field name="value">Masculino</field>
<field name="authority">DECSD008297</field>
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<field name="value">Regulación de la Expresión Génica</field>
<field name="authority">DECSD005786</field>
<field name="confidence">500</field>
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<field name="confidence">500</field>
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<field name="authority">DECSD000893</field>
<field name="confidence">500</field>
<field name="value">Humanos</field>
<field name="authority">DECSD006801</field>
<field name="confidence">500</field>
<field name="value">Obesidad</field>
<field name="authority">DECSD009765</field>
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<field name="confidence">500</field>
<field name="value">Inflamación</field>
<field name="authority">DECSD007249</field>
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<field name="value">A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome</field>
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<field name="value">Nutrients</field>
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