TDX
author
Fernandes Freitas, Dino Miguel
authoremail
dino.miguel.freitas@gmail.com
authoremailshow
false
director
Da Silva Bártolo, Paulo Jorge
director
Ciurana, Quim de
2020-03-18T11:32:48Z
2020-03-18T11:32:48Z
2019-11-29
http://hdl.handle.net/10803/668821
Tissue Engineering plays a vital role in tissue construct to repair, maintain or replace tissues. Those tissues can be cultivated in vivo or in vitro using devices such as bioreactors. There are several approaches to create the necessary tissues, but one of the most popular and successful is by using scaffold constructs to provide the required stability and support. After the cells being implanted on the scaffolds, they are then inserted in the bioreactors. Those bioreactors seek to mimic the conditions provided to cells by the human body. This issue by itself presents several challenges where it is required, to bioreactors, besides the optimum environment in terms of temperature, nutrients, the creation of the necessary stimulus to cells to differentiate and proliferate. In this work, is presented a novel concept of bioreactor for Tissue Engineering that can provide multiples stimulus when cultivating the tissue. To achieve an optimised design was performed several numerical simulations to access the best design parameters. For this, it was taken into account several variables such as fluid velocity, the proximity of the inlet/outlet to the scaffold, directions of the fluid and the impact of the liquid on the scaffold and subsequently the cells by analysing the wall shear stress provoked by the fluid flow
eng
Tissue engineering
Enginyeria de teixits
Ingeniería de tejidos
Scaffold
Bioreactors
Bioreactores
Biomedicine
Biomedicina
Numerical simulation
Simulació numèrica
Simulación numérica
Mechanical stimulation
Estimulació mecànica
Estimulación mecánica
Perfusion
Perfusió
Perfusión
A mechano-perfusion bioreactor for tissue engineering
info:eu-repo/semantics/doctoralThesis
URL
http://www.tdx.cat/bitstream/10803/668821/2/tdmff_20191129.pdf
File
MD5
cf968f0d6d847de33475d544dd2888dc
14705782
application/pdf
tdmff_20191129.pdf