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18F-FDG PET/CT in the follow-up of large-vessel vasculitis: A study of 37 consecutive patients

Identificadores del recurso

0049-0172

1532-866X

http://hdl.handle.net/10902/12792

10.1016/j.semarthrit.2017.08.009

Procedencia

(Repositorio Abierto de la Universidad de Cantabria)

Ficha

Título:: 18F-FDG PET/CT in the follow-up of large-vessel vasculitis: A study of 37 consecutive patients
Tema:: Large vessel vasculitis; 18F-FDG PET/CT; Positrón emission tomography; Aortitis, giant cell arteritis
Descrición:: Objective 18F-FDG PET/CT has proved to be of potential value for early diagnosis of large-vessel vasculitis (LVV), which frequently involves the aorta. However, its role in the follow-up of these patients has not been well established. Our aim was to evaluate the contribution of 18F-FDG PET/CT in this clinical situation. Methods This study included 37 consecutive patients (28 women, 66.5 ± 9.9 years) with an initial 18F-FDG PET/CT positive for LVV and a mean ± standard deviation follow-up PET/CT of 7.5 ± 2.9 months after the initial scan. A semiquantitative analysis of aortic wall uptake was performed calculating the target-to-background ratio (TBR: aortic wall uptake divided by blood pool uptake). The initial and follow-up TBR as well as the clinical and laboratory outcome were compared. Results Overall, the mean TBR decreased from 1.7 ± 0.5 at the initial scan to 1.5 ± 0.3 at the time of follow-up (p = 0.0001). In the 21 patients who experienced clinical improvement following therapy the TBR also decreased from 1.8 ± 0.6 to 1.5 ± 0.3 (p = 0.0002). However, in the other 16 patients, in whom the treating physician considered that there was no clinical improvement following therapy, no statistically significant differences in TBR were found when data from the first and the follow-up PET/CT scans were compared (1.6 ± 0.3 versus 1.5 ± 0.3, p = 0.1416). Patients who experienced clinical improvement following therapy showed a nonstatistically significant higher TBR at the time of disease diagnosis (1.8 ± 0.6 versus 1.6 ± 0.3; p = 0.12). Conclusions The results obtained in the present study highlight the impact of 18F-FDG PET/CT on the management of patients with LVV.; Professor Gonzalez-Gay´s research was supported by “Fondo de Investigación Sanitaria” (grant PI12/00060 and PI15/00525) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). His work is also partially supported by RETICS Programs RD12/0009 (RIER) from ISCIII (Spain) (RD16/0012/0009).
Fonte:: Seminars in Arthritis and Rheumatism Volume 47, Issue 4, February 2018, Pages 530-537
Idioma:: English
Relación:: https://doi.org/10.1016/j.semarthrit.2017.08.009
Autor/Productor:: Martínez Rodríguez, Mª Isabel; Jiménez Alonso, Mikel; Quirce Pisano, María Remedios; Jimenez Bonilla, Julio Francisco; Martínez Amador, Néstor; Arcocha Torres, María de; Loricera García, Javier; Blanco Alonso, Ricardo; González-Gay Mantecón, Miguel Ángel; Banzo, Ignacio
Editor:: Elsevier
Otros colaboradores/productores:: Universidad de Cantabria
Dereitos:: © <2018> Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license; http://creativecommons.org/licenses/by-nc-nd/4.0/; openAccess
Data:: 2018-01-09T14:39:24Z; 2019-02-01T03:45:10Z; 2018-02
Tipo de recurso:: info:eu-repo/semantics/article; acceptedVersion

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13. <dc:subject>Large vessel vasculitis</dc:subject>
14. <dc:subject>18F-FDG PET/CT</dc:subject>
15. <dc:subject>Positrón emission tomography</dc:subject>
16. <dc:subject>Aortitis, giant cell arteritis</dc:subject>
17. <dc:description>Objective 18F-FDG PET/CT has proved to be of potential value for early diagnosis of large-vessel vasculitis (LVV), which frequently involves the aorta. However, its role in the follow-up of these patients has not been well established. Our aim was to evaluate the contribution of 18F-FDG PET/CT in this clinical situation. Methods This study included 37 consecutive patients (28 women, 66.5 ± 9.9 years) with an initial 18F-FDG PET/CT positive for LVV and a mean ± standard deviation follow-up PET/CT of 7.5 ± 2.9 months after the initial scan. A semiquantitative analysis of aortic wall uptake was performed calculating the target-to-background ratio (TBR: aortic wall uptake divided by blood pool uptake). The initial and follow-up TBR as well as the clinical and laboratory outcome were compared. Results Overall, the mean TBR decreased from 1.7 ± 0.5 at the initial scan to 1.5 ± 0.3 at the time of follow-up (p = 0.0001). In the 21 patients who experienced clinical improvement following therapy the TBR also decreased from 1.8 ± 0.6 to 1.5 ± 0.3 (p = 0.0002). However, in the other 16 patients, in whom the treating physician considered that there was no clinical improvement following therapy, no statistically significant differences in TBR were found when data from the first and the follow-up PET/CT scans were compared (1.6 ± 0.3 versus 1.5 ± 0.3, p = 0.1416). Patients who experienced clinical improvement following therapy showed a nonstatistically significant higher TBR at the time of disease diagnosis (1.8 ± 0.6 versus 1.6 ± 0.3; p = 0.12). Conclusions The results obtained in the present study highlight the impact of 18F-FDG PET/CT on the management of patients with LVV.</dc:description>
18. <dc:description>Professor Gonzalez-Gay´s research was supported by “Fondo de Investigación Sanitaria” (grant PI12/00060 and PI15/00525) from “Instituto de Salud Carlos III” (ISCIII, Health Ministry, Spain). His work is also partially supported by RETICS Programs RD12/0009 (RIER) from ISCIII (Spain) (RD16/0012/0009).</dc:description>
19. <dc:date>2018-01-09T14:39:24Z</dc:date>
20. <dc:date>2019-02-01T03:45:10Z</dc:date>
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  4. <dc:creator>Quirce Pisano, María Remedios</dc:creator>
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  13. <dc:description lang="es_ES">Objective 18F-FDG PET/CT has proved to be of potential value for early diagnosis of large-vessel vasculitis (LVV), which frequently involves the aorta. However, its role in the follow-up of these patients has not been well established. Our aim was to evaluate the contribution of 18F-FDG PET/CT in this clinical situation. Methods This study included 37 consecutive patients (28 women, 66.5 ± 9.9 years) with an initial 18F-FDG PET/CT positive for LVV and a mean ± standard deviation follow-up PET/CT of 7.5 ± 2.9 months after the initial scan. A semiquantitative analysis of aortic wall uptake was performed calculating the target-to-background ratio (TBR: aortic wall uptake divided by blood pool uptake). The initial and follow-up TBR as well as the clinical and laboratory outcome were compared. Results Overall, the mean TBR decreased from 1.7 ± 0.5 at the initial scan to 1.5 ± 0.3 at the time of follow-up (p = 0.0001). In the 21 patients who experienced clinical improvement following therapy the TBR also decreased from 1.8 ± 0.6 to 1.5 ± 0.3 (p = 0.0002). However, in the other 16 patients, in whom the treating physician considered that there was no clinical improvement following therapy, no statistically significant differences in TBR were found when data from the first and the follow-up PET/CT scans were compared (1.6 ± 0.3 versus 1.5 ± 0.3, p = 0.1416). Patients who experienced clinical improvement following therapy showed a nonstatistically significant higher TBR at the time of disease diagnosis (1.8 ± 0.6 versus 1.6 ± 0.3; p = 0.12). Conclusions The results obtained in the present study highlight the impact of 18F-FDG PET/CT on the management of patients with LVV.</dc:description>
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