Hispana. Acceso en línea al Patrimonio Cultural Digital Español

Está en:  › Datos do registro

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes

Identificadores del recurso

https://oa.upm.es/16431/

Procedencia

(Archivo Digital UPM)

Ficha

Título:: Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes
Tema:: Matemáticas
Descrición:: Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.
Fonte:: Plos One, ISSN 1932-6203, 2012-08-07, Vol. 7, No. 8
Idioma:: English
Relación:: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042494; info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0042494
Autor/Productor:: Dueñas, Marta; Santos, Mirentxu; Aranda, Juan F.; Bielza Lozoya, María Concepción; Martínez-Cruz, Ana B.; Lorz, Corina; Taron, Miquel; Ciruelos, Eva M.; Rodríguez-Peralto, José L.; Martín Jiménez, Miguel; Larrañaga Múgica, Pedro María; Dahabreh, Jubrail; Stathopoulos, George P.; Rosell, Rafael; Paramio, Jesús M.; García-Escudero, Ramón
Editor:: Facultad de Informática (UPM)
Dereitos:: https://creativecommons.org/licenses/by-nc-nd/3.0/es/; info:eu-repo/semantics/openAccess
Data:: 2012-08-07
Tipo de recurso:: info:eu-repo/semantics/article; Artículo; PeerReviewed
Formato:: application/pdf

oai_dc

Descargar XML

<?xml version="1.0" encoding="UTF-8" ?>

<oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
1. <dc:title>Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes</dc:title>
2. <dc:creator>Dueñas, Marta</dc:creator>
3. <dc:creator>Santos, Mirentxu</dc:creator>
4. <dc:creator>Aranda, Juan F.</dc:creator>
5. <dc:creator>Bielza Lozoya, María Concepción</dc:creator>
6. <dc:creator>Martínez-Cruz, Ana B.</dc:creator>
7. <dc:creator>Lorz, Corina</dc:creator>
8. <dc:creator>Taron, Miquel</dc:creator>
9. <dc:creator>Ciruelos, Eva M.</dc:creator>
10. <dc:creator>Rodríguez-Peralto, José L.</dc:creator>
11. <dc:creator>Martín Jiménez, Miguel</dc:creator>
12. <dc:creator>Larrañaga Múgica, Pedro María</dc:creator>
13. <dc:creator>Dahabreh, Jubrail</dc:creator>
14. <dc:creator>Stathopoulos, George P.</dc:creator>
15. <dc:creator>Rosell, Rafael</dc:creator>
16. <dc:creator>Paramio, Jesús M.</dc:creator>
17. <dc:creator>García-Escudero, Ramón</dc:creator>
18. <dc:subject>Matemáticas</dc:subject>
19. <dc:description>Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.</dc:description>
20. <dc:publisher>Facultad de Informática (UPM)</dc:publisher>
21. <dc:rights>https://creativecommons.org/licenses/by-nc-nd/3.0/es/</dc:rights>
22. <dc:date>2012-08-07</dc:date>
23. <dc:type>info:eu-repo/semantics/article</dc:type>
24. <dc:type>Artículo</dc:type>
25. <dc:source>Plos One, ISSN 1932-6203, 2012-08-07, Vol. 7, No. 8</dc:source>
26. <dc:type>PeerReviewed</dc:type>
27. <dc:format>application/pdf</dc:format>
28. <dc:language>eng</dc:language>
29. <dc:relation>http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042494</dc:relation>
30. <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
31. <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0042494</dc:relation>
32. <dc:identifier>https://oa.upm.es/16431/</dc:identifier>
</oai_dc:dc>

datacite

Descargar XML

<?xml version="1.0" encoding="UTF-8" ?>

<resource schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.4/metadata.xsd">
1. <identifier identifierType="DOI">10.1371/journal.pone.0042494</identifier>
2. <relatedIdentifiers>
 1. <relatedIdentifier relatedIdentifierType="URL" relationType="IsIdenticalTo">https://oa.upm.es/16431/1/INVE_MEM_2012_133787.pdf</relatedIdentifier>
 </relatedIdentifiers>
3. <titles>
 1. <title>Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes</title>
 </titles>
4. <creators>
 1. <creator>
 1. <creatorName nameType="Personal">Dueñas, Marta</creatorName>
 2. <givenName>Marta</givenName>
 3. <familyName>Dueñas</familyName>
 </creator>
 2. <creator>
 1. <creatorName nameType="Personal">Santos, Mirentxu</creatorName>
 2. <givenName>Mirentxu</givenName>
 3. <familyName>Santos</familyName>
 </creator>
 3. <creator>
 1. <creatorName nameType="Personal">Aranda, Juan F.</creatorName>
 2. <givenName>Juan F.</givenName>
 3. <familyName>Aranda</familyName>
 </creator>
 4. <creator>
 1. <creatorName nameType="Personal">Bielza Lozoya, María Concepción</creatorName>
 2. <givenName>María Concepción</givenName>
 3. <familyName>Bielza Lozoya</familyName>
 4. <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0001-7109-2668</nameIdentifier>
 </creator>
 5. <creator>
 1. <creatorName nameType="Personal">Martínez-Cruz, Ana B.</creatorName>
 2. <givenName>Ana B.</givenName>
 3. <familyName>Martínez-Cruz</familyName>
 </creator>
 6. <creator>
 1. <creatorName nameType="Personal">Lorz, Corina</creatorName>
 2. <givenName>Corina</givenName>
 3. <familyName>Lorz</familyName>
 </creator>
 7. <creator>
 1. <creatorName nameType="Personal">Taron, Miquel</creatorName>
 2. <givenName>Miquel</givenName>
 3. <familyName>Taron</familyName>
 </creator>
 8. <creator>
 1. <creatorName nameType="Personal">Ciruelos, Eva M.</creatorName>
 2. <givenName>Eva M.</givenName>
 3. <familyName>Ciruelos</familyName>
 </creator>
 9. <creator>
 1. <creatorName nameType="Personal">Rodríguez-Peralto, José L.</creatorName>
 2. <givenName>José L.</givenName>
 3. <familyName>Rodríguez-Peralto</familyName>
 </creator>
 10. <creator>
 1. <creatorName nameType="Personal">Martín Jiménez, Miguel</creatorName>
 2. <givenName>Miguel</givenName>
 3. <familyName>Martín Jiménez</familyName>
 </creator>
 11. <creator>
 1. <creatorName nameType="Personal">Larrañaga Múgica, Pedro María</creatorName>
 2. <givenName>Pedro María</givenName>
 3. <familyName>Larrañaga Múgica</familyName>
 4. <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0652-9872</nameIdentifier>
 </creator>
 12. <creator>
 1. <creatorName nameType="Personal">Dahabreh, Jubrail</creatorName>
 2. <givenName>Jubrail</givenName>
 3. <familyName>Dahabreh</familyName>
 </creator>
 13. <creator>
 1. <creatorName nameType="Personal">Stathopoulos, George P.</creatorName>
 2. <givenName>George P.</givenName>
 3. <familyName>Stathopoulos</familyName>
 </creator>
 14. <creator>
 1. <creatorName nameType="Personal">Rosell, Rafael</creatorName>
 2. <givenName>Rafael</givenName>
 3. <familyName>Rosell</familyName>
 </creator>
 15. <creator>
 1. <creatorName nameType="Personal">Paramio, Jesús M.</creatorName>
 2. <givenName>Jesús M.</givenName>
 3. <familyName>Paramio</familyName>
 </creator>
 16. <creator>
 1. <creatorName nameType="Personal">García-Escudero, Ramón</creatorName>
 2. <givenName>Ramón</givenName>
 3. <familyName>García-Escudero</familyName>
 </creator>
 </creators>
5. <contributors>
 1. <contributor>
 1. <contributorName nameType="Personal">none supplied</contributorName>
 </contributor>
 </contributors>
6. <editors>
 1. <editor />
 2. <editorName nameType="Personal">none supplied</editorName>
 </editors>
7. <descriptions>
 1. <description descriptionType="Abstract">Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.</description>
 </descriptions>
8. <subjects>
 1. <subject>Matemáticas</subject>
 </subjects>
9. <publicationYear>2012</publicationYear>
10. <publisher>Universidad Politécnica de Madrid</publisher>
</resource>

didl

Descargar XML

<?xml version="1.0" encoding="UTF-8" ?>

<didl:DIDL DIDLDocumentId="https://oa.upm.es/id/eprint/16431" schemaLocation="urn:mpeg:mpeg21:2002:02-DIDL-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/did/didl.xsd urn:mpeg:mpeg21:2002:01-DII-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/dii/dii.xsd urn:mpeg:mpeg21:2005:01-DIP-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/dip/dip.xsd">
1. <didl:Item>
 1. <didl:Descriptor>
 1. <didl:Statement mimeType="application/xml">
 1. <dii:Identifier>https://oa.upm.es/id/eprint/16431</dii:Identifier>
 </didl:Statement>
 </didl:Descriptor>
 2. <didl:Descriptor>
 1. <didl:Statement mimeType="application/xml">
 1. <dcterms:modified>2024-04-13T20:10:52Z</dcterms:modified>
 </didl:Statement>
 </didl:Descriptor>
 3. <didl:Component>
 1. <didl:Resource mimeType="application/xml" ref="https://oa.upm.es/cgi/export/eprint/16431/DIDL/upm-eprint-16431.xml" />
 </didl:Component>
 4. <didl:Item>
 1. <didl:Descriptor>
 1. <didl:Statement mimeType="application/xml">
 <dip:ObjectType>info:eu-repo/semantics/descriptiveMetadata</dip:ObjectType>
 </didl:Statement>
 </didl:Descriptor>
 2. <didl:Component>
 1. <didl:Resource mimeType="application/xml">
 <oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
 <dc:title>Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes</dc:title>
 <dc:creator>Dueñas, Marta</dc:creator>
 <dc:creator>Santos, Mirentxu</dc:creator>
 <dc:creator>Aranda, Juan F.</dc:creator>
 <dc:creator>Bielza Lozoya, María Concepción</dc:creator>
 <dc:creator>Martínez-Cruz, Ana B.</dc:creator>
 <dc:creator>Lorz, Corina</dc:creator>
 <dc:creator>Taron, Miquel</dc:creator>
 <dc:creator>Ciruelos, Eva M.</dc:creator>
 <dc:creator>Rodríguez-Peralto, José L.</dc:creator>
 <dc:creator>Martín Jiménez, Miguel</dc:creator>
 <dc:creator>Larrañaga Múgica, Pedro María</dc:creator>
 <dc:creator>Dahabreh, Jubrail</dc:creator>
 <dc:creator>Stathopoulos, George P.</dc:creator>
 <dc:creator>Rosell, Rafael</dc:creator>
 <dc:creator>Paramio, Jesús M.</dc:creator>
 <dc:creator>García-Escudero, Ramón</dc:creator>
 <dc:subject>Matemáticas</dc:subject>
 <dc:description>Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.</dc:description>
 <dc:publisher>Facultad de Informática (UPM)</dc:publisher>
 <dc:rights>https://creativecommons.org/licenses/by-nc-nd/3.0/es/</dc:rights>
 <dc:date>2012-08-07</dc:date>
 <dc:type>info:eu-repo/semantics/article</dc:type>
 <dc:type>Artículo</dc:type>
 <dc:source>Plos One, ISSN 1932-6203, 2012-08-07, Vol. 7, No. 8</dc:source>
 <dc:type>PeerReviewed</dc:type>
 <dc:format>application/pdf</dc:format>
 <dc:language>eng</dc:language>
 <dc:relation>http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042494</dc:relation>
 <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
 <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0042494</dc:relation>
 <dc:identifier>https://oa.upm.es/16431/</dc:identifier>
 </oai_dc:dc>
 </didl:Resource>
 </didl:Component>
 </didl:Item>
 5. <didl:Item>
 1. <didl:Descriptor>
 1. <didl:Statement mimeType="application/xml">
 <dip:ObjectType>info:eu-repo/semantics/objectFile</dip:ObjectType>
 </didl:Statement>
 </didl:Descriptor>
 2. <didl:Component>
 1. <didl:Resource mimeType="application/pdf" ref="https://oa.upm.es/16431/1/INVE_MEM_2012_133787.pdf" />
 </didl:Component>
 </didl:Item>
 6. <didl:Item>
 1. <didl:Descriptor>
 1. <didl:Statement mimeType="application/xml">
 <dip:ObjectType>info:eu-repo/semantics/humanStartPage</dip:ObjectType>
 </didl:Statement>
 </didl:Descriptor>
 2. <didl:Component>
 1. <didl:Resource mimeType="application/html" ref="https://oa.upm.es/16431/" />
 </didl:Component>
 </didl:Item>
 </didl:Item>
</didl:DIDL>

imarina

Descargar XML

<?xml version="1.0" encoding="UTF-8" ?>

<oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
1. <dc:title>Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes</dc:title>
2. <dc:creator>Dueñas, Marta</dc:creator>
3. <dc:creator>Santos, Mirentxu</dc:creator>
4. <dc:creator>Aranda, Juan F.</dc:creator>
5. <dc:creator>Bielza Lozoya, María Concepción ; orcid:0000-0001-7109-2668</dc:creator>
6. <dc:creator>Martínez-Cruz, Ana B.</dc:creator>
7. <dc:creator>Lorz, Corina</dc:creator>
8. <dc:creator>Taron, Miquel</dc:creator>
9. <dc:creator>Ciruelos, Eva M.</dc:creator>
10. <dc:creator>Rodríguez-Peralto, José L.</dc:creator>
11. <dc:creator>Martín Jiménez, Miguel</dc:creator>
12. <dc:creator>Larrañaga Múgica, Pedro María ; orcid:0000-0003-0652-9872</dc:creator>
13. <dc:creator>Dahabreh, Jubrail</dc:creator>
14. <dc:creator>Stathopoulos, George P.</dc:creator>
15. <dc:creator>Rosell, Rafael</dc:creator>
16. <dc:creator>Paramio, Jesús M.</dc:creator>
17. <dc:creator>García-Escudero, Ramón</dc:creator>
18. <dc:subject>Matemáticas</dc:subject>
19. <dc:description>Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.</dc:description>
20. <dc:publisher>Facultad de Informática (UPM)</dc:publisher>
21. <dc:rights>https://creativecommons.org/licenses/by-nc-nd/3.0/es/</dc:rights>
22. <dc:date>2012-08-07</dc:date>
23. <dc:type>info:eu-repo/semantics/article</dc:type>
24. <dc:type>Artículo</dc:type>
25. <dc:source>Plos One, ISSN 1932-6203, 2012-08-07, Vol. 7, No. 8</dc:source>
26. <dc:type>PeerReviewed</dc:type>
27. <dc:format>application/pdf</dc:format>
28. <dc:language>eng</dc:language>
29. <dc:relation>http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042494</dc:relation>
30. <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
31. <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0042494</dc:relation>
32. <dc:identifier>https://oa.upm.es/16431/</dc:identifier>
</oai_dc:dc>

mets

Descargar XML

<?xml version="1.0" encoding="UTF-8" ?>

<mets:mets LABEL="Eprints Item" OBJID="eprint_16431" schemaLocation="http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-3.xsd">
1. <mets:metsHdr CREATEDATE="2024-04-14T15:59:42Z">
 1. <mets:agent ROLE="CUSTODIAN" TYPE="ORGANIZATION">
 1. <mets:name>Archivo Digital UPM</mets:name>
 </mets:agent>
 </mets:metsHdr>
2. <mets:dmdSec ID="DMD_eprint_16431_mods">
 1. <mets:mdWrap MDTYPE="MODS">
 1. <mets:xmlData>
 1. <mods:titleInfo>
 <mods:title>Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes</mods:title>
 </mods:titleInfo>
 2. <mods:name type="personal">
 <mods:namePart type="given">Marta</mods:namePart>
 <mods:namePart type="family">Dueñas</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 3. <mods:name type="personal">
 <mods:namePart type="given">Mirentxu</mods:namePart>
 <mods:namePart type="family">Santos</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 4. <mods:name type="personal">
 <mods:namePart type="given">Juan F.</mods:namePart>
 <mods:namePart type="family">Aranda</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 5. <mods:name type="personal">
 <mods:namePart type="given">María Concepción</mods:namePart>
 <mods:namePart type="family">Bielza Lozoya</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 6. <mods:name type="personal">
 <mods:namePart type="given">Ana B.</mods:namePart>
 <mods:namePart type="family">Martínez-Cruz</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 7. <mods:name type="personal">
 <mods:namePart type="given">Corina</mods:namePart>
 <mods:namePart type="family">Lorz</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 8. <mods:name type="personal">
 <mods:namePart type="given">Miquel</mods:namePart>
 <mods:namePart type="family">Taron</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 9. <mods:name type="personal">
 <mods:namePart type="given">Eva M.</mods:namePart>
 <mods:namePart type="family">Ciruelos</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 10. <mods:name type="personal">
 <mods:namePart type="given">José L.</mods:namePart>
 <mods:namePart type="family">Rodríguez-Peralto</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 11. <mods:name type="personal">
 <mods:namePart type="given">Miguel</mods:namePart>
 <mods:namePart type="family">Martín Jiménez</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 12. <mods:name type="personal">
 <mods:namePart type="given">Pedro María</mods:namePart>
 <mods:namePart type="family">Larrañaga Múgica</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 13. <mods:name type="personal">
 <mods:namePart type="given">Jubrail</mods:namePart>
 <mods:namePart type="family">Dahabreh</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 14. <mods:name type="personal">
 <mods:namePart type="given">George P.</mods:namePart>
 <mods:namePart type="family">Stathopoulos</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 15. <mods:name type="personal">
 <mods:namePart type="given">Rafael</mods:namePart>
 <mods:namePart type="family">Rosell</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 16. <mods:name type="personal">
 <mods:namePart type="given">Jesús M.</mods:namePart>
 <mods:namePart type="family">Paramio</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 17. <mods:name type="personal">
 <mods:namePart type="given">Ramón</mods:namePart>
 <mods:namePart type="family">García-Escudero</mods:namePart>
 <mods:role>
 <mods:roleTerm type="text">author</mods:roleTerm>
 </mods:role>
 </mods:name>
 18. <mods:abstract>Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.</mods:abstract>
 19. <mods:classification authority="lcc">Matemáticas</mods:classification>
 20. <mods:originInfo>
 <mods:dateIssued encoding="iso8601">2012-08-07</mods:dateIssued>
 </mods:originInfo>
 21. <mods:originInfo>
 <mods:publisher>Public Library of Science</mods:publisher>
 </mods:originInfo>
 22. <mods:genre>Artículo</mods:genre>
 </mets:xmlData>
 </mets:mdWrap>
 </mets:dmdSec>
3. <mets:amdSec ID="TMD_eprint_16431">
 1. <mets:rightsMD ID="rights_eprint_16431_mods">
 1. <mets:mdWrap MDTYPE="MODS">
 1. <mets:xmlData>
 <mods:useAndReproduction>
 
 
 <a href="mailto:archivo.digital@upm.es">archivo.digital@upm.es</a>
 
 
 El autor declara que es el titular de los derechos de propiedad intelectual, objeto de la presente cesión, en relación con la obra que autoarchiva, que ésta es una obra original, y que ostenta la condición de autor de esta obra.
 En caso de ser cotitular de tales derechos, el autor declara que cuenta con la autorización de los restantes titulares para hacer la presente cesión, y que los nombres de todos los coautores aparecen mencionados en la obra.
 En caso de previa cesión a terceros de derechos de explotación de la obra, el autor declara que tiene la oportuna reserva o autorización de dichos titulares de derechos a los fines de esta cesión.
 Con el fin de dar la máxima difusión a esta obra a través de internet, el autor cede a la Universidad Politécnica de Madrid, de forma gratuita y no exclusiva, por el máximo plazo legal y con ámbito universal, los derechos de reproducción, de distribución, de comunicación pública, incluido el derecho de puesta a disposición electrónica, para que pueda ser utilizada de forma libre y gratuita por todos los usuarios de internet, siempre que se cite su autoría y su uso se ajuste a las licencia Creative Commons elegida. Se entienden autorizados todos los actos necesarios para el registro de la obra, su seguridad y su conservación.
 El autor garantiza que el compromiso que aquí adquiere no infringe ningú n derecho de propiedad industrial, intelectual, derecho al honor, intimidad, o imagen, o cualquier otro derecho de terceros.
 El autor asume toda reclamación que pudiera ejercitarse contra la Universidad por terceros que vieran infringidos sus derechos a causa de la cesión.
 El autor renuncia a cualquier reclamación frente a la Universidad por las formas no ajustadas a la legislación vigente en que los usuarios hagan uso de las obras.
 
 <a href="mailto:archivo.digital@upm.es">archivo.digital@upm.es</a>
 
 
 Para trabajos depositados por otros que no sean su autor:
 UPM
 
 Pulsar en el botón de depósitar E-print Ahora indica su aceptación de estos términos.
 </mods:useAndReproduction>
 </mets:xmlData>
 </mets:mdWrap>
 </mets:rightsMD>
 </mets:amdSec>
4. <mets:fileSec>
 1. <mets:fileGrp USE="reference">
 1. <mets:file ID="eprint_16431_21139_1" MIMETYPE="application/pdf" OWNERID="https://oa.upm.es/16431/1/INVE_MEM_2012_133787.pdf" SIZE="1231302">
 1. <mets:FLocat LOCTYPE="URL" href="https://oa.upm.es/16431/1/INVE_MEM_2012_133787.pdf" type="simple" />
 </mets:file>
 </mets:fileGrp>
 </mets:fileSec>
5. <mets:structMap>
 1. <mets:div ADMID="TMD_eprint_16431" DMDID="DMD_eprint_16431_mods">
 1. <mets:fptr FILEID="eprint_16431_document_21139_1" />
 </mets:div>
 </mets:structMap>
</mets:mets>

oai_bibl

Descargar XML

<?xml version="1.0" encoding="UTF-8" ?>

<oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd" />

rdf

Descargar XML

<?xml version="1.0" encoding="UTF-8" ?>

<rdf:RDF>
1. <rdf:Description about="">
 1. <foaf:primaryTopic resource="https://oa.upm.es/id/eprint/16431" />
 2. <rdfs:comment datatype="http://www.w3.org/2001/XMLSchema#string">The repository administrator has not yet configured an RDF license.</rdfs:comment>
 </rdf:Description>
2. <rdf:Description about="https://oa.upm.es/16431/1/INVE_MEM_2012_133787.pdf">
 1. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">INVE_MEM_2012_133787.pdf</rdfs:label>
 </rdf:Description>
3. <rdf:Description about="https://oa.upm.es/16431/3/indexcodes.txt">
 1. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">indexcodes.txt</rdfs:label>
 </rdf:Description>
4. <rdf:Description about="https://oa.upm.es/16431/4/lightbox.jpg">
 1. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">lightbox.jpg</rdfs:label>
 </rdf:Description>
5. <rdf:Description about="https://oa.upm.es/16431/5/preview.jpg">
 1. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">preview.jpg</rdfs:label>
 </rdf:Description>
6. <rdf:Description about="https://oa.upm.es/16431/6/medium.jpg">
 1. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">medium.jpg</rdfs:label>
 </rdf:Description>
7. <rdf:Description about="https://oa.upm.es/16431/7/small.jpg">
 1. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">small.jpg</rdfs:label>
 </rdf:Description>
8. <rdf:Description about="https://oa.upm.es/16431/">
 1. <dc:format>text/html</dc:format>
 2. <dc:title>HTML Summary of #16431 Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes</dc:title>
 3. <foaf:primaryTopic resource="https://oa.upm.es/id/eprint/16431" />
 </rdf:Description>
9. <rdf:Description about="https://oa.upm.es/id/document/21139">
 1. <dct:hasPart resource="https://oa.upm.es/16431/1/INVE_MEM_2012_133787.pdf" />
 2. <ep:hasFile resource="https://oa.upm.es/16431/1/INVE_MEM_2012_133787.pdf" />
 3. <rdf:type resource="http://purl.org/ontology/bibo/Document" />
 4. <rdf:type resource="http://eprints.org/ontology/Document" />
 5. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes (PDF (Portable Document Format))</rdfs:label>
 </rdf:Description>
10. <rdf:Description about="https://oa.upm.es/id/document/63400">
 1. <dct:hasPart resource="https://oa.upm.es/16431/3/indexcodes.txt" />
 2. <ep:hasFile resource="https://oa.upm.es/16431/3/indexcodes.txt" />
 3. <eprel:isIndexCodesVersionOf resource="https://oa.upm.es/id/document/21139" />
 4. <eprel:isVersionOf resource="https://oa.upm.es/id/document/21139" />
 5. <eprel:isVolatileVersionOf resource="https://oa.upm.es/id/document/21139" />
 6. <rdf:type resource="http://eprints.org/ontology/Document" />
 7. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes (Otro)</rdfs:label>
 </rdf:Description>
11. <rdf:Description about="https://oa.upm.es/id/document/251871">
 1. <dct:hasPart resource="https://oa.upm.es/16431/4/lightbox.jpg" />
 2. <ep:hasFile resource="https://oa.upm.es/16431/4/lightbox.jpg" />
 3. <eprel:isVersionOf resource="https://oa.upm.es/id/document/21139" />
 4. <eprel:isVolatileVersionOf resource="https://oa.upm.es/id/document/21139" />
 5. <eprel:islightboxThumbnailVersionOf resource="https://oa.upm.es/id/document/21139" />
 6. <rdf:type resource="http://eprints.org/ontology/Document" />
 7. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes (Otro)</rdfs:label>
 </rdf:Description>
12. <rdf:Description about="https://oa.upm.es/id/document/251873">
 1. <dct:hasPart resource="https://oa.upm.es/16431/5/preview.jpg" />
 2. <ep:hasFile resource="https://oa.upm.es/16431/5/preview.jpg" />
 3. <eprel:isVersionOf resource="https://oa.upm.es/id/document/21139" />
 4. <eprel:isVolatileVersionOf resource="https://oa.upm.es/id/document/21139" />
 5. <eprel:ispreviewThumbnailVersionOf resource="https://oa.upm.es/id/document/21139" />
 6. <rdf:type resource="http://eprints.org/ontology/Document" />
 7. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes (Otro)</rdfs:label>
 </rdf:Description>
13. <rdf:Description about="https://oa.upm.es/id/document/251874">
 1. <dct:hasPart resource="https://oa.upm.es/16431/6/medium.jpg" />
 2. <ep:hasFile resource="https://oa.upm.es/16431/6/medium.jpg" />
 3. <eprel:isVersionOf resource="https://oa.upm.es/id/document/21139" />
 4. <eprel:isVolatileVersionOf resource="https://oa.upm.es/id/document/21139" />
 5. <eprel:ismediumThumbnailVersionOf resource="https://oa.upm.es/id/document/21139" />
 6. <rdf:type resource="http://eprints.org/ontology/Document" />
 7. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes (Otro)</rdfs:label>
 </rdf:Description>
14. <rdf:Description about="https://oa.upm.es/id/document/251875">
 1. <dct:hasPart resource="https://oa.upm.es/16431/7/small.jpg" />
 2. <ep:hasFile resource="https://oa.upm.es/16431/7/small.jpg" />
 3. <eprel:isVersionOf resource="https://oa.upm.es/id/document/21139" />
 4. <eprel:isVolatileVersionOf resource="https://oa.upm.es/id/document/21139" />
 5. <eprel:issmallThumbnailVersionOf resource="https://oa.upm.es/id/document/21139" />
 6. <rdf:type resource="http://eprints.org/ontology/Document" />
 7. <rdfs:label datatype="http://www.w3.org/2001/XMLSchema#string">Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes (Otro)</rdfs:label>
 </rdf:Description>
15. <rdf:Description about="https://oa.upm.es/id/eprint/16431#authors">
 1. <rdf:_1 resource="https://oa.upm.es/id/person/ext-7ff8cf9453ad71bbd50a226271e043b9" />
 2. <rdf:_2 resource="https://oa.upm.es/id/person/ext-048363f2430ab764d622b844c3b650a7" />
 3. <rdf:_3 resource="https://oa.upm.es/id/person/ext-67f86ae4d43628de961e6a7340c2c745" />
 4. <rdf:_4 resource="https://oa.upm.es/id/person/ext-c.bielza@upm.es" />
 5. <rdf:_5 resource="https://oa.upm.es/id/person/ext-cd1272b7e077be20d6ca6ef82d5a6e11" />
 6. <rdf:_6 resource="https://oa.upm.es/id/person/ext-d674934228576d2ade629bf395f9d722" />
 7. <rdf:_7 resource="https://oa.upm.es/id/person/ext-7a4412a79383b6e648d931f4c9d62c3e" />
 8. <rdf:_8 resource="https://oa.upm.es/id/person/ext-965c9a144a5e8a0d18474e22bb0e8624" />
 9. <rdf:_9 resource="https://oa.upm.es/id/person/ext-f7ddb3b4c631e3226dbd13e713297353" />
 10. <rdf:_10 resource="https://oa.upm.es/id/person/ext-44f403231f7fe51ef438bd2e20a7975f" />
 11. <rdf:_11 resource="https://oa.upm.es/id/person/ext-pedro.larranaga@upm.es" />
 12. <rdf:_12 resource="https://oa.upm.es/id/person/ext-4a3cb357dcc8e3af7163dc2ac66181f6" />
 13. <rdf:_13 resource="https://oa.upm.es/id/person/ext-1b21d2569f6dd8f40233745ae80c99dd" />
 14. <rdf:_14 resource="https://oa.upm.es/id/person/ext-1be390eb283169e41d2d8e8507a299d7" />
 15. <rdf:_15 resource="https://oa.upm.es/id/person/ext-8749f142d86ef0befe9b9aae9aa19c29" />
 16. <rdf:_16 resource="https://oa.upm.es/id/person/ext-e83d6231102ecd24263b2f5a94ca1db2" />
 </rdf:Description>
16. <rdf:Description about="https://oa.upm.es/id/eprint/16431">
 1. <bibo:abstract datatype="http://www.w3.org/2001/XMLSchema#string">Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.</bibo:abstract>
 2. <bibo:authorList resource="https://oa.upm.es/id/eprint/16431#authors" />
 3. <bibo:issue>8</bibo:issue>
 4. <bibo:status resource="http://purl.org/ontology/bibo/status/peerReviewed" />
 5. <bibo:status resource="http://purl.org/ontology/bibo/status/published" />
 6. <bibo:volume>7</bibo:volume>
 7. <dct:creator resource="https://oa.upm.es/id/person/ext-1b21d2569f6dd8f40233745ae80c99dd" />
 8. <dct:creator resource="https://oa.upm.es/id/person/ext-1be390eb283169e41d2d8e8507a299d7" />
 9. <dct:creator resource="https://oa.upm.es/id/person/ext-4a3cb357dcc8e3af7163dc2ac66181f6" />
 10. <dct:creator resource="https://oa.upm.es/id/person/ext-7a4412a79383b6e648d931f4c9d62c3e" />
 11. <dct:creator resource="https://oa.upm.es/id/person/ext-7ff8cf9453ad71bbd50a226271e043b9" />
 12. <dct:creator resource="https://oa.upm.es/id/person/ext-44f403231f7fe51ef438bd2e20a7975f" />
 13. <dct:creator resource="https://oa.upm.es/id/person/ext-67f86ae4d43628de961e6a7340c2c745" />
 14. <dct:creator resource="https://oa.upm.es/id/person/ext-965c9a144a5e8a0d18474e22bb0e8624" />
 15. <dct:creator resource="https://oa.upm.es/id/person/ext-8749f142d86ef0befe9b9aae9aa19c29" />
 16. <dct:creator resource="https://oa.upm.es/id/person/ext-048363f2430ab764d622b844c3b650a7" />
 17. <dct:creator resource="https://oa.upm.es/id/person/ext-c.bielza@upm.es" />
 18. <dct:creator resource="https://oa.upm.es/id/person/ext-cd1272b7e077be20d6ca6ef82d5a6e11" />
 19. <dct:creator resource="https://oa.upm.es/id/person/ext-d674934228576d2ade629bf395f9d722" />
 20. <dct:creator resource="https://oa.upm.es/id/person/ext-e83d6231102ecd24263b2f5a94ca1db2" />
 21. <dct:creator resource="https://oa.upm.es/id/person/ext-f7ddb3b4c631e3226dbd13e713297353" />
 22. <dct:creator resource="https://oa.upm.es/id/person/ext-pedro.larranaga@upm.es" />
 23. <dct:date>2012-08-07</dct:date>
 24. <dct:isPartOf resource="https://oa.upm.es/id/repository" />
 25. <dct:isPartOf resource="https://oa.upm.es/id/publication/ext-19326203" />
 26. <dct:publisher resource="https://oa.upm.es/id/org/ext-72433582b3abfd9f3b74d94a6e694560" />
 27. <dct:subject resource="https://oa.upm.es/id/subject/matematicas" />
 28. <dct:title datatype="http://www.w3.org/2001/XMLSchema#string">Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes</dct:title>
 29. <ep:hasDocument resource="https://oa.upm.es/id/document/21139" />
 30. <ep:hasDocument resource="https://oa.upm.es/id/document/63400" />
 31. <ep:hasDocument resource="https://oa.upm.es/id/document/251871" />
 32. <ep:hasDocument resource="https://oa.upm.es/id/document/251873" />
 33. <ep:hasDocument resource="https://oa.upm.es/id/document/251874" />
 34. <ep:hasDocument resource="https://oa.upm.es/id/document/251875" />
 35. <owl:sameAs resource="https://doi.org/10.1371/journal.pone.0042494" />
 36. <rdf:type resource="http://purl.org/ontology/bibo/AcademicArticle" />
 37. <rdf:type resource="http://purl.org/ontology/bibo/Article" />
 38. <rdf:type resource="http://eprints.org/ontology/ArticleEPrint" />
 39. <rdf:type resource="http://eprints.org/ontology/EPrint" />
 40. <rdfs:seeAlso resource="https://oa.upm.es/16431/" />
 </rdf:Description>
17. <rdf:Description about="https://oa.upm.es/id/subject/matematicas">
 1. <rdf:type resource="http://www.w3.org/2004/02/skos/core#Concept" />
 2. <skos:prefLabel lang="es">Matemáticas</skos:prefLabel>
 3. <skos:prefLabel lang="en">Mathematics</skos:prefLabel>
 </rdf:Description>
18. <rdf:Description about="https://oa.upm.es/id/org/ext-72433582b3abfd9f3b74d94a6e694560">
 1. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Public Library of Science</foaf:name>
 2. <rdf:type resource="http://xmlns.com/foaf/0.1/Organization" />
 </rdf:Description>
19. <rdf:Description about="https://oa.upm.es/id/person/ext-1b21d2569f6dd8f40233745ae80c99dd">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Stathopoulos</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">George P.</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">George P. Stathopoulos</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
20. <rdf:Description about="https://oa.upm.es/id/person/ext-1be390eb283169e41d2d8e8507a299d7">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Rosell</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Rafael</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Rafael Rosell</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
21. <rdf:Description about="https://oa.upm.es/id/person/ext-4a3cb357dcc8e3af7163dc2ac66181f6">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Dahabreh</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Jubrail</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Jubrail Dahabreh</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
22. <rdf:Description about="https://oa.upm.es/id/person/ext-7a4412a79383b6e648d931f4c9d62c3e">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Taron</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Miquel</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Miquel Taron</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
23. <rdf:Description about="https://oa.upm.es/id/person/ext-7ff8cf9453ad71bbd50a226271e043b9">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Dueñas</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Marta</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Marta Dueñas</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
24. <rdf:Description about="https://oa.upm.es/id/person/ext-44f403231f7fe51ef438bd2e20a7975f">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Martín Jiménez</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Miguel</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Miguel Martín Jiménez</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
25. <rdf:Description about="https://oa.upm.es/id/person/ext-67f86ae4d43628de961e6a7340c2c745">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Aranda</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Juan F.</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Juan F. Aranda</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
26. <rdf:Description about="https://oa.upm.es/id/person/ext-965c9a144a5e8a0d18474e22bb0e8624">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Ciruelos</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Eva M.</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Eva M. Ciruelos</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
27. <rdf:Description about="https://oa.upm.es/id/person/ext-8749f142d86ef0befe9b9aae9aa19c29">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Paramio</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Jesús M.</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Jesús M. Paramio</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
28. <rdf:Description about="https://oa.upm.es/id/person/ext-048363f2430ab764d622b844c3b650a7">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Santos</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Mirentxu</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Mirentxu Santos</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
29. <rdf:Description about="https://oa.upm.es/id/person/ext-c.bielza@upm.es">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Bielza Lozoya</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">María Concepción</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">María Concepción Bielza Lozoya</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
30. <rdf:Description about="https://oa.upm.es/id/person/ext-cd1272b7e077be20d6ca6ef82d5a6e11">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Martínez-Cruz</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Ana B.</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Ana B. Martínez-Cruz</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
31. <rdf:Description about="https://oa.upm.es/id/person/ext-d674934228576d2ade629bf395f9d722">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Lorz</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Corina</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Corina Lorz</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
32. <rdf:Description about="https://oa.upm.es/id/person/ext-e83d6231102ecd24263b2f5a94ca1db2">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">García-Escudero</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Ramón</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Ramón García-Escudero</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
33. <rdf:Description about="https://oa.upm.es/id/person/ext-f7ddb3b4c631e3226dbd13e713297353">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Rodríguez-Peralto</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">José L.</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">José L. Rodríguez-Peralto</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
34. <rdf:Description about="https://oa.upm.es/id/person/ext-pedro.larranaga@upm.es">
 1. <foaf:familyName datatype="http://www.w3.org/2001/XMLSchema#string">Larrañaga Múgica</foaf:familyName>
 2. <foaf:givenName datatype="http://www.w3.org/2001/XMLSchema#string">Pedro María</foaf:givenName>
 3. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Pedro María Larrañaga Múgica</foaf:name>
 4. <rdf:type resource="http://xmlns.com/foaf/0.1/Person" />
 </rdf:Description>
35. <rdf:Description about="https://oa.upm.es/id/publication/ext-19326203">
 1. <bibo:issn>19326203</bibo:issn>
 2. <foaf:name datatype="http://www.w3.org/2001/XMLSchema#string">Plos One</foaf:name>
 3. <owl:sameAs resource="urn:issn:19326203" />
 4. <rdf:type resource="http://purl.org/ontology/bibo/Collection" />
 </rdf:Description>
</rdf:RDF>

uketd_dc

Descargar XML

<?xml version="1.0" encoding="UTF-8" ?>

<uketd_dc:uketddc schemaLocation="http://naca.central.cranfield.ac.uk/ethos-oai/2.0/ http://naca.central.cranfield.ac.uk/ethos-oai/2.0/uketd_dc.xsd" />