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3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing

Identificadores del recurso

Carbohydrate Polymers 278 (2022) 118924

http://hdl.handle.net/10347/27437

10.1016/j.carbpol.2021.118924

0144-8617

Jatorria

(Minerva. Repositorio Institucional da Universidade de Santiago de Compostela)

Fitxa

Izenburu:: 3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing
Tema:: Carboxymethyl cellulose; 3D printing; Rheological properties; MicroCT; Platelet rich plasma; Wound healing; Cell mobility; Angiogenesis
Deskribapen:: This work aims to use carboxymethyl cellulose (CMC) as main structural and functional component of 3D printed scaffolds for healing of diabetic wounds. Differently from previous inks involving small contents in CMC, herein sterile (steam-heated) concentrated CMC solely dispersions (10–20%w/v) were screened regarding printability and fidelity properties. CMC (15%w/v)-citric acid inks showed excellent self-healing rheological properties and stability during storage. CMC scaffolds loaded with platelet rich plasma (PRP) sustained the release of relevant growth factors. CMC scaffolds both with and without PRP promoted angiogenesis in ovo, stem cell migration in vitro, and wound healing in a diabetic model in vivo. Transparent CMC scaffolds allowed direct monitoring of bilateral full-thickness wounds created in rat dorsum. CMC scaffolds facilitated re-epithelialization, granulation, and angiogenesis in full-thickness skin defects, and the performance was improved when combined with PRP. Overall, CMC is pointed out as outstanding component of active dressings for diabetic wounds; SI
Idioma:: English
Harreman:: https://doi.org/10.1016/j.carbpol.2021.118924
Autor/Productor:: Díaz Gómez, Luis Antonio; González Prada, Iago; Millán Lence, Rosendo; Silva Candal, Andrés da; Bugallo Casal, Ana; Campos Pérez, Francisco; Concheiro Nine, Ángel Joaquín; Álvarez Lorenzo, Carmen Isabel
Argitaratzaile:: Elsevier
Otros colaboradores/productores:: Universidade de Santiago de Compostela. Departamento de Farmacia e Tecnoloxía Farmacéutica; Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
Eskubideak:: © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)2; Attribution-NonCommercial-NoDerivatives 4.0 Internacional; http://creativecommons.org/licenses/by-nc-nd/4.0/; info:eu-repo/semantics/openAccess
Data:: 2022-01-31T09:11:52Z; 2022
Tipo de recurso:: info:eu-repo/semantics/article; info:eu-repo/semantics/draft
Formatu:: application/pdf

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4. <dc:creator>Millán Lence, Rosendo</dc:creator>
5. <dc:creator>Silva Candal, Andrés da</dc:creator>
6. <dc:creator>Bugallo Casal, Ana</dc:creator>
7. <dc:creator>Campos Pérez, Francisco</dc:creator>
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14. <dc:subject>Rheological properties</dc:subject>
15. <dc:subject>MicroCT</dc:subject>
16. <dc:subject>Platelet rich plasma</dc:subject>
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18. <dc:subject>Cell mobility</dc:subject>
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20. <dc:description>This work aims to use carboxymethyl cellulose (CMC) as main structural and functional component of 3D printed scaffolds for healing of diabetic wounds. Differently from previous inks involving small contents in CMC, herein sterile (steam-heated) concentrated CMC solely dispersions (10–20%w/v) were screened regarding printability and fidelity properties. CMC (15%w/v)-citric acid inks showed excellent self-healing rheological properties and stability during storage. CMC scaffolds loaded with platelet rich plasma (PRP) sustained the release of relevant growth factors. CMC scaffolds both with and without PRP promoted angiogenesis in ovo, stem cell migration in vitro, and wound healing in a diabetic model in vivo. Transparent CMC scaffolds allowed direct monitoring of bilateral full-thickness wounds created in rat dorsum. CMC scaffolds facilitated re-epithelialization, granulation, and angiogenesis in full-thickness skin defects, and the performance was improved when combined with PRP. Overall, CMC is pointed out as outstanding component of active dressings for diabetic wounds</dc:description>
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