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β-catenin signalling in Glioblastoma multiforme and Glioma-initiating cells

Identificadores del recurso

2090-2107

http://hdl.handle.net/10459.1/46382

https://doi.org/10.1155/2012/192362

Procedencia

(Repositori Obert UdL)

Ficha

Título:: β-catenin signalling in Glioblastoma multiforme and Glioma-initiating cells
Tema:: GBM; GBM Recurrence; Cervell -- Tumors; Sistema nerviós central -- Tumors; Càncer; Cèl·lules -- Proliferació; Neurobiologia; Proteïnes -- Anàlisi
Descripción:: Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis. GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into the surrounding tissue. Following treatment (surgery, radiotherapy, and chemotherapy), tumors often reappear. Glioma-initiating cells (GICs) have been identified in GBM and are thought to be responsible for tumors initiation, their continued growth, and recurrence. β-catenin, a component of the cell-cell adhesion complex and of the canonical Wnt pathway, regulates proliferation, adhesion, and migration in different cell types. β-catenin and components of the Wnt canonical pathway are commonly overexpressed in GBM. Here, we review previous work on the role of Wnt/β-catenin signalling in glioma initiation, proliferation, and invasion. Understanding the molecular mechanisms regulating GIC biology and glioma progression may help in identifying novel therapeutic targets for GBM treatment.
Idioma:: English
Relación:: Reproducció del document publicat a: https://doi.org/10.1155/2012/192362; Chemotherapy Research and Practice, 2012, vol. 2012, ID 192362, p. 1-7
Autor/Productor:: Nàger Grifo, Mireia; Bhardwaj, Deepshikha; Cantí Nicolás, Carles; Medina Hernández, Loreta Mª; Nogués Bara, Pere; Herreros Danés, Judit
Editor:: Hindawi Publishing Corporation
Derechos:: cc-by, (c) Mireia Nager et al., 2012; http://creativecommons.org/licenses/by/3.0/es/deed.ca; info:eu-repo/semantics/openAccess
Fecha:: 2013-01-08T09:07:56Z; 2012
Tipo de recurso:: article; publishedVersion

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