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3D printed pellets (miniprintlets): A novel, multi-drug, controlled release platform technology

Identificadores del recurso

Awad, A.; Fina, F.; Trenfield, S.J.; Patel, P.; Goyanes, A.; Gaisford, S.; Basit, A.W. 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology. Pharmaceutics 2019, 11, 148

http://hdl.handle.net/10347/21148

10.3390/pharmaceutics11040148

1999-4923

Procedencia

(Minerva. Repositorio Institucional da Universidade de Santiago de Compostela)

Ficha

Título:: 3D printed pellets (miniprintlets): A novel, multi-drug, controlled release platform technology
Tema:: Three dimensional printing; Additive manufacturing; 3D printed drug product; Printlets; Personalised medicines; Personalized pharmaceuticals; Multiple units; Spheroids; Beads; Acetaminophen; 3209
Descripción:: [ENG]Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties. As such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated in 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional monolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns. The possibility of producing miniprintlets combining two drugs, namely paracetamol and ibuprofen, was also investigated. By varying the polymer, the dual miniprintlets were programmed to achieve customised drug release patterns, whereby one drug was released immediately from a Kollicoat Instant Release matrix, whilst the effect of the second drug was sustained over an extended time span using ethyl cellulose. Herein, this work has highlighted the versatility of SLS 3DP to fabricate small and intricate formulations containing multiple active pharmaceutical ingredients with distinct release properties; SI
Idioma:: English
Relación:: https://doi.org/10.3390/pharmaceutics11040148
Autor/Productor:: Awad, Atheer; Fina, Fabrizio; Trenfield, Sarah J.; Patel, Pavanesh; Goyanes Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W.
Editor:: MDPI
Otros colaboradores/productores:: Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
Derechos:: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/); open access
Fecha:: 2020-04-03T16:40:55Z; 2019
Tipo de recurso:: journal article; VoR

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1. <dc:title>3D printed pellets (miniprintlets): A novel, multi-drug, controlled release platform technology</dc:title>
2. <dc:creator>Awad, Atheer</dc:creator>
3. <dc:creator>Fina, Fabrizio</dc:creator>
4. <dc:creator>Trenfield, Sarah J.</dc:creator>
5. <dc:creator>Patel, Pavanesh</dc:creator>
6. <dc:creator>Goyanes Goyanes, Álvaro</dc:creator>
7. <dc:creator>Gaisford, Simon</dc:creator>
8. <dc:creator>Basit, Abdul W.</dc:creator>
9. <dc:contributor>Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica</dc:contributor>
10. <dc:subject>Three dimensional printing</dc:subject>
11. <dc:subject>Additive manufacturing</dc:subject>
12. <dc:subject>3D printed drug product</dc:subject>
13. <dc:subject>Printlets</dc:subject>
14. <dc:subject>Personalised medicines</dc:subject>
15. <dc:subject>Personalized pharmaceuticals</dc:subject>
16. <dc:subject>Multiple units</dc:subject>
17. <dc:subject>Spheroids</dc:subject>
18. <dc:subject>Beads</dc:subject>
19. <dc:subject>Acetaminophen</dc:subject>
20. <dc:subject>3209</dc:subject>
21. <dc:description>[ENG]Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties. As such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated in 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional monolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns. The possibility of producing miniprintlets combining two drugs, namely paracetamol and ibuprofen, was also investigated. By varying the polymer, the dual miniprintlets were programmed to achieve customised drug release patterns, whereby one drug was released immediately from a Kollicoat Instant Release matrix, whilst the effect of the second drug was sustained over an extended time span using ethyl cellulose. Herein, this work has highlighted the versatility of SLS 3DP to fabricate small and intricate formulations containing multiple active pharmaceutical ingredients with distinct release properties</dc:description>
22. <dc:description>SI</dc:description>
23. <dc:date>2020-04-03T16:40:55Z</dc:date>
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29. <dc:identifier>http://hdl.handle.net/10347/21148</dc:identifier>
30. <dc:identifier>10.3390/pharmaceutics11040148</dc:identifier>
31. <dc:identifier>1999-4923</dc:identifier>
32. <dc:language>eng</dc:language>
33. <dc:relation>https://doi.org/10.3390/pharmaceutics11040148</dc:relation>
34. <dc:rights>© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)</dc:rights>
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