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1D alignment of proteins and other nanoparticles by using reversible covalent bonds on cyclic peptide nanotubes

Identificadores del recurso

Org. Chem. Front., 2022,9, 1226-1233 https://doi.org/10.1039/D1QO01349A

2052-4110

http://hdl.handle.net/10347/29370

10.1039/D1QO01349A

2052-4129

Procedencia

(Minerva. Repositorio Institucional da Universidade de Santiago de Compostela)

Ficha

Título:: 1D alignment of proteins and other nanoparticles by using reversible covalent bonds on cyclic peptide nanotubes
Descripción:: Self-assembling cyclic peptide nanotubes are supramolecular structures whose diameter and external surface properties are precisely controlled. In this communication we describe a general strategy to align different molecules on top of the nanotube surface by using cyclic peptides bearing chemoreversible reactive groups. D,L-α-Cyclic peptides endowed with a hydrazide moiety were condensed with a pyrenecarboxyaldehyde to facilitate the nanotube formation and deposition on flat unfunctionalized surfaces. The hydrazide moieties can be liberated without affecting the tubular structure and then used to align on top of the nanotube other molecules bearing aldehyde functions. Additionally, the attachment of specific ligands allowed the supramolecular alignment of corresponding receptors, such as mannosyl aldehyde and concavaline-A, driven by the nanotube structure through complemetary protein–ligand interactions; This work was supported by the Spanish Agencia Estatal de Investigación (AEI) and the ERDF (PID2019 111126RB-100, SAF2017-89890-R, EIG_JC2018-054), and by the Xunta de Galicia and the ERDF (ED431C 2017/25 and Centro singular de Investigación de Galicia accreditation 2019-2022, ED431G 2019/03). We also thank the ORFEO-CINCA network and Mineco (RED2018-102331-T). J.M.P. thanks to the Ministerio de Educación y Cultura (MEC) for his FPI contract. J.M. received an ISCIII (COV20/00297), ERC - Stg (DYNAP-677786), ERC-PoC (TraffikGene, 838002),and a YIG from the HFSP (RGY0066/2017); SI
Idioma:: English
Relación:: https://doi.org/10.1039/D1QO01349A; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111126RB-100/ES; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89890-R/ES/PEPTIDOS HIBRIDOS PARA EL TRANSPORTE SELECTIVO Y ENTREGA DE PROTEINAS TERAPEUTICAS
Autor/Productor:: Priegue Caamaño, Juan Manuel; Louzao Pernas, Iria; Gallego Gómez, Iván; Montenegro García, Javier; Granja Guillán, Juan Ramón
Editor:: Royal Society of Chemistry
Otros colaboradores/productores:: Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares; Universidade de Santiago de Compostela. Departamento de Química Orgánica
Derechos:: © The Royal Society of Chemistry, 2021; embargoed access
Fecha:: 2022-10-31T12:15:33Z; 2022-12-20T02:00:09Z; 2021
Tipo de recurso:: journal article; AM

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2. <dc:creator>Priegue Caamaño, Juan Manuel</dc:creator>
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10. <dc:description>This work was supported by the Spanish Agencia Estatal de Investigación (AEI) and the ERDF (PID2019 111126RB-100, SAF2017-89890-R, EIG_JC2018-054), and by the Xunta de Galicia and the ERDF (ED431C 2017/25 and Centro singular de Investigación de Galicia accreditation 2019-2022, ED431G 2019/03). We also thank the ORFEO-CINCA network and Mineco (RED2018-102331-T). J.M.P. thanks to the Ministerio de Educación y Cultura (MEC) for his FPI contract. J.M. received an ISCIII (COV20/00297), ERC - Stg (DYNAP-677786), ERC-PoC (TraffikGene, 838002),and a YIG from the HFSP (RGY0066/2017)</dc:description>
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14. <dc:date>2021</dc:date>
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18. <dc:identifier>2052-4110</dc:identifier>
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