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3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method

Identificadores del recurso

Robles-Martinez, P.; Xu, X.; Trenfield, S.J.; Awad, A.; Goyanes, A.; Telford, R.; Basit, A.W.; Gaisford, S. 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method. Pharmaceutics 2019, 11, 274

http://hdl.handle.net/10347/21335

10.3390/pharmaceutics11060274

1999-4923

Procedencia

(Minerva. Repositorio Institucional da Universidade de Santiago de Compostela)

Ficha

Título:: 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method
Tema:: Three-dimensional printing; Additive manufacturing; Printlets; Tablets; Personalized medicines; Multiple-layer dosage forms; Stereolithography; Vat polymerisation
Descripción:: Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, caffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed with different geometries and material compositions. Drug distribution was visualised using Raman microscopy, which showed that whilst separate layers were successfully printed, several of the drugs diffused across the layers depending on their amorphous or crystalline phase. The printed constructs demonstrated excellent physical properties and the different material inclusions enabled distinct drug release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a new era of personalised polypills; The authors thank the Engineering and Physical Sciences Research Council (EPSRC), UK for their financial support (EP/L01646X); SI
Idioma:: English
Relación:: https://doi.org/10.3390/pharmaceutics11060274
Autor/Productor:: Robles Martínez, Pamela; Xu, Xiaoyan; Trenfield, Sarah J.; Awad, Atheer; Goyanes Goyanes, Álvaro; Telford, Richard; Basit, Abdul W.; Gaisford, Simon
Editor:: MDPI
Otros colaboradores/productores:: Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
Derechos:: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/); https://creativecommons.org/licenses/by/4.0/; open access
Fecha:: 2020-04-13T20:57:00Z; 2019
Tipo de recurso:: journal article; VoR

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1. <dc:title>3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method</dc:title>
2. <dc:creator>Robles Martínez, Pamela</dc:creator>
3. <dc:creator>Xu, Xiaoyan</dc:creator>
4. <dc:creator>Trenfield, Sarah J.</dc:creator>
5. <dc:creator>Awad, Atheer</dc:creator>
6. <dc:creator>Goyanes Goyanes, Álvaro</dc:creator>
7. <dc:creator>Telford, Richard</dc:creator>
8. <dc:creator>Basit, Abdul W.</dc:creator>
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10. <dc:contributor>Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica</dc:contributor>
11. <dc:subject>Three-dimensional printing</dc:subject>
12. <dc:subject>Additive manufacturing</dc:subject>
13. <dc:subject>Printlets</dc:subject>
14. <dc:subject>Tablets</dc:subject>
15. <dc:subject>Personalized medicines</dc:subject>
16. <dc:subject>Multiple-layer dosage forms</dc:subject>
17. <dc:subject>Stereolithography</dc:subject>
18. <dc:subject>Vat polymerisation</dc:subject>
19. <dc:description>Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, caffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed with different geometries and material compositions. Drug distribution was visualised using Raman microscopy, which showed that whilst separate layers were successfully printed, several of the drugs diffused across the layers depending on their amorphous or crystalline phase. The printed constructs demonstrated excellent physical properties and the different material inclusions enabled distinct drug release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a new era of personalised polypills</dc:description>
20. <dc:description>The authors thank the Engineering and Physical Sciences Research Council (EPSRC), UK for their financial support (EP/L01646X)</dc:description>
21. <dc:description>SI</dc:description>
22. <dc:date>2020-04-13T20:57:00Z</dc:date>
23. <dc:date>2020-04-13T20:57:00Z</dc:date>
24. <dc:date>2019</dc:date>
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31. <dc:language>eng</dc:language>
32. <dc:relation>https://doi.org/10.3390/pharmaceutics11060274</dc:relation>
33. <dc:rights>© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)</dc:rights>
34. <dc:rights>https://creativecommons.org/licenses/by/4.0/</dc:rights>
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