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Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes

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https://oa.upm.es/16431/

Procedencia

(Archivo Digital UPM)

Ficha

Título:: Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes
Tema:: Matemáticas
Descripción:: Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.
Fuente:: Plos One, ISSN 1932-6203, 2012-08-07, Vol. 7, No. 8
Idioma:: English
Relación:: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0042494; info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0042494
Autor/Productor:: Dueñas, Marta; Santos, Mirentxu; Aranda, Juan F.; Bielza Lozoya, María Concepción; Martínez-Cruz, Ana B.; Lorz, Corina; Taron, Miquel; Ciruelos, Eva M.; Rodríguez-Peralto, José L.; Martín Jiménez, Miguel; Larrañaga Múgica, Pedro María; Dahabreh, Jubrail; Stathopoulos, George P.; Rosell, Rafael; Paramio, Jesús M.; García-Escudero, Ramón
Editor:: Facultad de Informática (UPM)
Derechos:: https://creativecommons.org/licenses/by-nc-nd/3.0/es/; info:eu-repo/semantics/openAccess
Fecha:: 2012-08-07
Tipo de recurso:: info:eu-repo/semantics/article; Artículo; PeerReviewed
Formato:: application/pdf

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uketd_dc

Descargar XML

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