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(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells

Identificadores del recurso

García-Vilas JA, Martínez-Poveda B, Quesada AR, Medina MÁ. (+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells. Marine Drugs. 2018; 16(9):316. https://doi.org/10.3390/md16090316

https://hdl.handle.net/10630/24104

10.3390/md16090316

Origin

(RIUMA: Repositorio Institucional Universidad Málaga)

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Title:: (+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
Tema:: Neovascularización; Aeroplysinin-1; Angiogenesis; Aplysina aerophoba; Endothelial cell; Redox
Description:: The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for (+)-aeroplysinin-1 in endothelial cells. The sequential use of 2D-electrophoresis and MALDI-TOF-TOF/MS allowed us to identify several differentially expressed proteins. Four of these proteins were involved in redox processes and were validated by Western blot. The effects of (+)-aeroplysinin-1 were further studied by testing the effects of the treatment with this compound on the activity of several anti- and pro-oxidant enzymes, as well as on transcription factors involved in redox homeostasis. Finally, changes in the levels of total reactive oxygen species and mitochondrial membrane potential induced by endothelial cell treatments with (+)-aeroplysinin-1 were also determined. Taken altogether, these findings show that (+)-aeroplysinin-1 has multiple targets involved in endothelial cell redox regulation.; Supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The “CIBER de Enfermedades Raras” is an initiative from the ISCIII (Spain). JAGV had the financial support of Vicerrectorado de Investigación y Transferencia (University of Málaga, Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. Partial funding for open access charge: Universidad de Málaga
Idioma:: English
Autor/Productor:: García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel
Publisher:: IOAP-MPDI
Rights:: info:eu-repo/semantics/openAccess; http://creativecommons.org/licenses/by/4.0/; Atribución 4.0 Internacional
Date:: 2022-05-13T11:31:47Z; 2018-09-06
Tipo de recurso:: info:eu-repo/semantics/article

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  1. <dc:title>(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells</dc:title>
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