<?xml version="1.0" encoding="UTF-8" ?>
<oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
<dc:title>2D printed multicellular devices performing digital and analogue computation</dc:title>
<dc:creator>Mogas Díez, Sira</dc:creator>
<dc:creator>González Flo, Eva, 1993-</dc:creator>
<dc:creator>Macía, Javier</dc:creator>
<dc:subject>Assay systems</dc:subject>
<dc:subject>Synthetic biology</dc:subject>
<dc:description>Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</dc:description>
<dc:description>Funding for this study and for the open access charge was in the form of grants from the Spanish Ministry of Economy and Competitiveness [MINECO AEI-FIS2017-88786-R and FEDER] and UPF INNOValora 2019 [INNOV19-01-1]. This work was supported by “Unidad de Excelencia María de Maeztu” and funded by the AEI (CEX2018-000792-M). E.G.F. is a recipient of an FI-DGR (2017 FI_B 00018) fellowship.</dc:description>
<dc:date>2021</dc:date>
<dc:type>info:eu-repo/semantics/article</dc:type>
<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
<dc:identifier>Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</dc:identifier>
<dc:identifier>2041-1723</dc:identifier>
<dc:identifier>http://hdl.handle.net/10230/47085</dc:identifier>
<dc:identifier>http://dx.doi.org/10.1038/s41467-021-21967-x</dc:identifier>
<dc:language>eng</dc:language>
<dc:relation>Nat Commun. 2021; 12(1):1679</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/ES/2PE/FIS2017-88786-R</dc:relation>
<dc:rights>© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</dc:rights>
<dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
<dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
<dc:format>application/pdf</dc:format>
<dc:publisher>Nature Research</dc:publisher>
</oai_dc:dc>
<?xml version="1.0" encoding="UTF-8" ?>
<d:DIDL schemaLocation="urn:mpeg:mpeg21:2002:02-DIDL-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/did/didl.xsd">
<d:DIDLInfo>
<dcterms:created schemaLocation="http://purl.org/dc/terms/ http://dublincore.org/schemas/xmls/qdc/dcterms.xsd">2021-04-12T07:07:16Z</dcterms:created>
</d:DIDLInfo>
<d:Item id="hdl_10230_47085">
<d:Descriptor>
<d:Statement mimeType="application/xml; charset=utf-8">
<dii:Identifier schemaLocation="urn:mpeg:mpeg21:2002:01-DII-NS http://standards.iso.org/ittf/PubliclyAvailableStandards/MPEG-21_schema_files/dii/dii.xsd">urn:hdl:10230/47085</dii:Identifier>
</d:Statement>
</d:Descriptor>
<d:Descriptor>
<d:Statement mimeType="application/xml; charset=utf-8">
<oai_dc:dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
<dc:title>2D printed multicellular devices performing digital and analogue computation</dc:title>
<dc:creator>Mogas Díez, Sira</dc:creator>
<dc:creator>González Flo, Eva, 1993-</dc:creator>
<dc:creator>Macía, Javier</dc:creator>
<dc:description>Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</dc:description>
<dc:date>2021-04-12T07:07:16Z</dc:date>
<dc:date>2021-04-12T07:07:16Z</dc:date>
<dc:date>2021</dc:date>
<dc:type>info:eu-repo/semantics/article</dc:type>
<dc:identifier>Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</dc:identifier>
<dc:identifier>2041-1723</dc:identifier>
<dc:identifier>http://hdl.handle.net/10230/47085</dc:identifier>
<dc:identifier>http://dx.doi.org/10.1038/s41467-021-21967-x</dc:identifier>
<dc:language>eng</dc:language>
<dc:relation>Nat Commun. 2021; 12(1):1679</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/ES/2PE/FIS2017-88786-R</dc:relation>
<dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
<dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
<dc:rights>© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</dc:rights>
<dc:publisher>Nature Research</dc:publisher>
</oai_dc:dc>
</d:Statement>
</d:Descriptor>
<d:Component id="10230_47085_1">
</d:Component>
</d:Item>
</d:DIDL>
<?xml version="1.0" encoding="UTF-8" ?>
<dim:dim schemaLocation="http://www.dspace.org/xmlns/dspace/dim http://www.dspace.org/schema/dim.xsd">
<dim:field element="contributor" mdschema="dc" qualifier="author">Mogas Díez, Sira</dim:field>
<dim:field element="contributor" mdschema="dc" qualifier="author">González Flo, Eva, 1993-</dim:field>
<dim:field element="contributor" mdschema="dc" qualifier="author">Macía, Javier</dim:field>
<dim:field element="date" mdschema="dc" qualifier="accessioned">2021-04-12T07:07:16Z</dim:field>
<dim:field element="date" mdschema="dc" qualifier="available">2021-04-12T07:07:16Z</dim:field>
<dim:field element="date" mdschema="dc" qualifier="issued">2021</dim:field>
<dim:field element="identifier" mdschema="dc" qualifier="citation">Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</dim:field>
<dim:field element="identifier" mdschema="dc" qualifier="issn">2041-1723</dim:field>
<dim:field element="identifier" mdschema="dc" qualifier="uri">http://hdl.handle.net/10230/47085</dim:field>
<dim:field element="identifier" mdschema="dc" qualifier="doi">http://dx.doi.org/10.1038/s41467-021-21967-x</dim:field>
<dim:field element="description" mdschema="dc" qualifier="abstract">Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</dim:field>
<dim:field element="description" lang="en" mdschema="dc" qualifier="provenance">Made available in DSpace on 2021-04-12T07:07:16Z (GMT). No. of bitstreams: 1 Mogas_nc_prin.pdf: 1237407 bytes, checksum: d42106e02c64831f8b97e30595639d6f (MD5) Previous issue date: 2021</dim:field>
<dim:field element="description" mdschema="dc" qualifier="sponsorship">Funding for this study and for the open access charge was in the form of grants from the Spanish Ministry of Economy and Competitiveness [MINECO AEI-FIS2017-88786-R and FEDER] and UPF INNOValora 2019 [INNOV19-01-1]. This work was supported by “Unidad de Excelencia María de Maeztu” and funded by the AEI (CEX2018-000792-M). E.G.F. is a recipient of an FI-DGR (2017 FI_B 00018) fellowship.</dim:field>
<dim:field element="format" mdschema="dc" qualifier="mimetype">application/pdf</dim:field>
<dim:field element="language" mdschema="dc" qualifier="iso">eng</dim:field>
<dim:field element="publisher" mdschema="dc">Nature Research</dim:field>
<dim:field element="relation" mdschema="dc" qualifier="ispartof">Nat Commun. 2021; 12(1):1679</dim:field>
<dim:field element="relation" mdschema="dc" qualifier="projectID">info:eu-repo/grantAgreement/ES/2PE/FIS2017-88786-R</dim:field>
<dim:field element="rights" mdschema="dc">© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</dim:field>
<dim:field element="rights" mdschema="dc" qualifier="uri">http://creativecommons.org/licenses/by/4.0/</dim:field>
<dim:field element="rights" mdschema="dc" qualifier="accessRights">info:eu-repo/semantics/openAccess</dim:field>
<dim:field element="title" mdschema="dc">2D printed multicellular devices performing digital and analogue computation</dim:field>
<dim:field element="type" mdschema="dc">info:eu-repo/semantics/article</dim:field>
<dim:field element="type" mdschema="dc" qualifier="version">info:eu-repo/semantics/publishedVersion</dim:field>
<dim:field element="subject" mdschema="dc" qualifier="keyword">Assay systems</dim:field>
<dim:field element="subject" mdschema="dc" qualifier="keyword">Synthetic biology</dim:field>
</dim:dim>
<?xml version="1.0" encoding="UTF-8" ?>
<thesis schemaLocation="http://www.ndltd.org/standards/metadata/etdms/1.0/ http://www.ndltd.org/standards/metadata/etdms/1.0/etdms.xsd">
<title>2D printed multicellular devices performing digital and analogue computation</title>
<creator>Mogas Díez, Sira</creator>
<creator>González Flo, Eva, 1993-</creator>
<creator>Macía, Javier</creator>
<description>Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</description>
<date>2021-04-12</date>
<date>2021-04-12</date>
<date>2021</date>
<type>info:eu-repo/semantics/article</type>
<identifier>Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</identifier>
<identifier>2041-1723</identifier>
<identifier>http://hdl.handle.net/10230/47085</identifier>
<identifier>http://dx.doi.org/10.1038/s41467-021-21967-x</identifier>
<language>eng</language>
<relation>Nat Commun. 2021; 12(1):1679</relation>
<relation>info:eu-repo/grantAgreement/ES/2PE/FIS2017-88786-R</relation>
<rights>http://creativecommons.org/licenses/by/4.0/</rights>
<rights>info:eu-repo/semantics/openAccess</rights>
<rights>© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</rights>
<publisher>Nature Research</publisher>
</thesis>
<?xml version="1.0" encoding="UTF-8" ?>
<record schemaLocation="http://www.loc.gov/MARC21/slim http://www.loc.gov/standards/marcxml/schema/MARC21slim.xsd">
<leader>00925njm 22002777a 4500</leader>
<datafield ind1=" " ind2=" " tag="042">
<subfield code="a">dc</subfield>
</datafield>
<datafield ind1=" " ind2=" " tag="720">
<subfield code="a">Mogas Díez, Sira</subfield>
<subfield code="e">author</subfield>
</datafield>
<datafield ind1=" " ind2=" " tag="720">
<subfield code="a">González Flo, Eva, 1993-</subfield>
<subfield code="e">author</subfield>
</datafield>
<datafield ind1=" " ind2=" " tag="720">
<subfield code="a">Macía, Javier</subfield>
<subfield code="e">author</subfield>
</datafield>
<datafield ind1=" " ind2=" " tag="260">
<subfield code="c">2021</subfield>
</datafield>
<datafield ind1=" " ind2=" " tag="520">
<subfield code="a">Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</subfield>
</datafield>
<datafield ind1="8" ind2=" " tag="024">
<subfield code="a">Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</subfield>
</datafield>
<datafield ind1="8" ind2=" " tag="024">
<subfield code="a">2041-1723</subfield>
</datafield>
<datafield ind1="8" ind2=" " tag="024">
<subfield code="a">http://hdl.handle.net/10230/47085</subfield>
</datafield>
<datafield ind1="8" ind2=" " tag="024">
<subfield code="a">http://dx.doi.org/10.1038/s41467-021-21967-x</subfield>
</datafield>
<datafield ind1="0" ind2="0" tag="245">
<subfield code="a">2D printed multicellular devices performing digital and analogue computation</subfield>
</datafield>
</record>
<?xml version="1.0" encoding="UTF-8" ?>
<mets ID=" DSpace_ITEM_10230-47085" OBJID=" hdl:10230/47085" PROFILE="DSpace METS SIP Profile 1.0" TYPE="DSpace ITEM" schemaLocation="http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd">
<metsHdr CREATEDATE="2022-11-16T01:40:22Z">
<agent ROLE="CUSTODIAN" TYPE="ORGANIZATION">
<name>Repositori digital de la UPF</name>
</agent>
</metsHdr>
<dmdSec ID="DMD_10230_47085">
<mdWrap MDTYPE="MODS">
<xmlData schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd">
<mods:mods schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd">
<mods:name>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
<mods:namePart>Mogas Díez, Sira</mods:namePart>
</mods:name>
<mods:name>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
<mods:namePart>González Flo, Eva, 1993-</mods:namePart>
</mods:name>
<mods:name>
<mods:role>
<mods:roleTerm type="text">author</mods:roleTerm>
</mods:role>
<mods:namePart>Macía, Javier</mods:namePart>
</mods:name>
<mods:extension>
<mods:dateAccessioned encoding="iso8601">2021-04-12T07:07:16Z</mods:dateAccessioned>
</mods:extension>
<mods:extension>
<mods:dateAvailable encoding="iso8601">2021-04-12T07:07:16Z</mods:dateAvailable>
</mods:extension>
<mods:originInfo>
<mods:dateIssued encoding="iso8601">2021</mods:dateIssued>
</mods:originInfo>
<mods:identifier type="citation">Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</mods:identifier>
<mods:identifier type="issn">2041-1723</mods:identifier>
<mods:identifier type="uri">http://hdl.handle.net/10230/47085</mods:identifier>
<mods:identifier type="doi">http://dx.doi.org/10.1038/s41467-021-21967-x</mods:identifier>
<mods:abstract>Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</mods:abstract>
<mods:language>
<mods:languageTerm authority="rfc3066">eng</mods:languageTerm>
</mods:language>
<mods:accessCondition type="useAndReproduction">© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</mods:accessCondition>
<mods:titleInfo>
<mods:title>2D printed multicellular devices performing digital and analogue computation</mods:title>
</mods:titleInfo>
<mods:genre>info:eu-repo/semantics/article</mods:genre>
</mods:mods>
</xmlData>
</mdWrap>
</dmdSec>
<amdSec ID="FO_10230_47085_1">
<techMD ID="TECH_O_10230_47085_1">
<mdWrap MDTYPE="PREMIS">
<xmlData schemaLocation="http://www.loc.gov/standards/premis http://www.loc.gov/standards/premis/PREMIS-v1-0.xsd">
<premis:premis>
<premis:object>
<premis:objectIdentifier>
<premis:objectIdentifierType>URL</premis:objectIdentifierType>
<premis:objectIdentifierValue>http://repositori.upf.edu/bitstream/10230/47085/1/Mogas_nc_prin.pdf</premis:objectIdentifierValue>
</premis:objectIdentifier>
<premis:objectCategory>File</premis:objectCategory>
<premis:objectCharacteristics>
<premis:fixity>
<premis:messageDigestAlgorithm>MD5</premis:messageDigestAlgorithm>
<premis:messageDigest>d42106e02c64831f8b97e30595639d6f</premis:messageDigest>
</premis:fixity>
<premis:size>1237407</premis:size>
<premis:format>
<premis:formatDesignation>
<premis:formatName>application/pdf</premis:formatName>
</premis:formatDesignation>
</premis:format>
</premis:objectCharacteristics>
<premis:originalName>Mogas_nc_prin.pdf</premis:originalName>
</premis:object>
</premis:premis>
</xmlData>
</mdWrap>
</techMD>
</amdSec>
<amdSec ID="FT_10230_47085_2">
<techMD ID="TECH_T_10230_47085_2">
<mdWrap MDTYPE="PREMIS">
<xmlData schemaLocation="http://www.loc.gov/standards/premis http://www.loc.gov/standards/premis/PREMIS-v1-0.xsd">
<premis:premis>
<premis:object>
<premis:objectIdentifier>
<premis:objectIdentifierType>URL</premis:objectIdentifierType>
<premis:objectIdentifierValue>http://repositori.upf.edu/bitstream/10230/47085/2/Mogas_nc_prin.pdf.txt</premis:objectIdentifierValue>
</premis:objectIdentifier>
<premis:objectCategory>File</premis:objectCategory>
<premis:objectCharacteristics>
<premis:fixity>
<premis:messageDigestAlgorithm>MD5</premis:messageDigestAlgorithm>
<premis:messageDigest>24df4f9bd93667406a12676df4746ce2</premis:messageDigest>
</premis:fixity>
<premis:size>49126</premis:size>
<premis:format>
<premis:formatDesignation>
<premis:formatName>text/plain</premis:formatName>
</premis:formatDesignation>
</premis:format>
</premis:objectCharacteristics>
<premis:originalName>Mogas_nc_prin.pdf.txt</premis:originalName>
</premis:object>
</premis:premis>
</xmlData>
</mdWrap>
</techMD>
</amdSec>
<fileSec>
<fileGrp USE="ORIGINAL">
<file ADMID="FO_10230_47085_1" CHECKSUM="d42106e02c64831f8b97e30595639d6f" CHECKSUMTYPE="MD5" GROUPID="GROUP_BITSTREAM_10230_47085_1" ID="BITSTREAM_ORIGINAL_10230_47085_1" MIMETYPE="application/pdf" SEQ="1" SIZE="1237407">
</file>
</fileGrp>
<fileGrp USE="TEXT">
<file ADMID="FT_10230_47085_2" CHECKSUM="24df4f9bd93667406a12676df4746ce2" CHECKSUMTYPE="MD5" GROUPID="GROUP_BITSTREAM_10230_47085_2" ID="BITSTREAM_TEXT_10230_47085_2" MIMETYPE="text/plain" SEQ="2" SIZE="49126">
</file>
</fileGrp>
</fileSec>
<structMap LABEL="DSpace Object" TYPE="LOGICAL">
<div ADMID="DMD_10230_47085" TYPE="DSpace Object Contents">
<div TYPE="DSpace BITSTREAM">
</div>
</div>
</structMap>
</mets>
<?xml version="1.0" encoding="UTF-8" ?>
<mods:mods schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-1.xsd">
<mods:name>
<mods:namePart>Mogas Díez, Sira</mods:namePart>
</mods:name>
<mods:name>
<mods:namePart>González Flo, Eva, 1993-</mods:namePart>
</mods:name>
<mods:name>
<mods:namePart>Macía, Javier</mods:namePart>
</mods:name>
<mods:extension>
<mods:dateAvailable encoding="iso8601">2021-04-12T07:07:16Z</mods:dateAvailable>
</mods:extension>
<mods:extension>
<mods:dateAccessioned encoding="iso8601">2021-04-12T07:07:16Z</mods:dateAccessioned>
</mods:extension>
<mods:originInfo>
<mods:dateIssued encoding="iso8601">2021</mods:dateIssued>
</mods:originInfo>
<mods:identifier type="citation">Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</mods:identifier>
<mods:identifier type="issn">2041-1723</mods:identifier>
<mods:identifier type="uri">http://hdl.handle.net/10230/47085</mods:identifier>
<mods:identifier type="doi">http://dx.doi.org/10.1038/s41467-021-21967-x</mods:identifier>
<mods:abstract>Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</mods:abstract>
<mods:language>
<mods:languageTerm>eng</mods:languageTerm>
</mods:language>
<mods:accessCondition type="useAndReproduction">http://creativecommons.org/licenses/by/4.0/</mods:accessCondition>
<mods:accessCondition type="useAndReproduction">info:eu-repo/semantics/openAccess</mods:accessCondition>
<mods:accessCondition type="useAndReproduction">© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</mods:accessCondition>
<mods:titleInfo>
<mods:title>2D printed multicellular devices performing digital and analogue computation</mods:title>
</mods:titleInfo>
<mods:genre>info:eu-repo/semantics/article</mods:genre>
</mods:mods>
<?xml version="1.0" encoding="UTF-8" ?>
<atom:entry schemaLocation="http://www.w3.org/2005/Atom http://www.kbcafe.com/rss/atom.xsd.xml">
<atom:id>http://oai-repositori.upf.edu/oai/metadata/handle/10230/47085/ore.xml</atom:id>
<atom:published>2021-04-12T07:07:16Z</atom:published>
<atom:updated>2021-04-12T07:07:16Z</atom:updated>
<atom:source>
<atom:generator>Repositori digital de la UPF</atom:generator>
</atom:source>
<atom:title>2D printed multicellular devices performing digital and analogue computation</atom:title>
<atom:author>
<atom:name>Mogas Díez, Sira</atom:name>
</atom:author>
<atom:author>
<atom:name>González Flo, Eva, 1993-</atom:name>
</atom:author>
<atom:author>
<atom:name>Macía, Javier</atom:name>
</atom:author>
<oreatom:triples>
<rdf:Description about="http://oai-repositori.upf.edu/oai/metadata/handle/10230/47085/ore.xml#atom">
<dcterms:modified>2021-04-12T07:07:16Z</dcterms:modified>
</rdf:Description>
<rdf:Description about="http://repositori.upf.edu/bitstream/10230/47085/3/Mogas_nc_prin.pdf.jpg">
<dcterms:description>THUMBNAIL</dcterms:description>
</rdf:Description>
<rdf:Description about="http://repositori.upf.edu/bitstream/10230/47085/2/Mogas_nc_prin.pdf.txt">
<dcterms:description>TEXT</dcterms:description>
</rdf:Description>
<rdf:Description about="http://repositori.upf.edu/bitstream/10230/47085/1/Mogas_nc_prin.pdf">
<dcterms:description>ORIGINAL</dcterms:description>
</rdf:Description>
</oreatom:triples>
</atom:entry>
<?xml version="1.0" encoding="UTF-8" ?>
<qdc:qualifieddc schemaLocation="http://purl.org/dc/elements/1.1/ http://dublincore.org/schemas/xmls/qdc/2006/01/06/dc.xsd http://purl.org/dc/terms/ http://dublincore.org/schemas/xmls/qdc/2006/01/06/dcterms.xsd http://dspace.org/qualifieddc/ http://www.ukoln.ac.uk/metadata/dcmi/xmlschema/qualifieddc.xsd">
<dc:title>2D printed multicellular devices performing digital and analogue computation</dc:title>
<dc:creator>Mogas Díez, Sira</dc:creator>
<dc:creator>González Flo, Eva, 1993-</dc:creator>
<dc:creator>Macía, Javier</dc:creator>
<dcterms:abstract>Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</dcterms:abstract>
<dc:date>2021</dc:date>
<dc:type>info:eu-repo/semantics/article</dc:type>
<dc:identifier>Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</dc:identifier>
<dc:identifier>2041-1723</dc:identifier>
<dc:identifier>http://hdl.handle.net/10230/47085</dc:identifier>
<dc:identifier>http://dx.doi.org/10.1038/s41467-021-21967-x</dc:identifier>
<dc:language>eng</dc:language>
<dc:relation>Nat Commun. 2021; 12(1):1679</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/ES/2PE/FIS2017-88786-R</dc:relation>
<dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
<dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
<dc:rights>© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</dc:rights>
<dc:publisher>Nature Research</dc:publisher>
</qdc:qualifieddc>
<?xml version="1.0" encoding="UTF-8" ?>
<rdf:RDF schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
<ow:Publication about="oai:repositori.upf.edu:10230/47085">
<dc:title>2D printed multicellular devices performing digital and analogue computation</dc:title>
<dc:creator>Mogas Díez, Sira</dc:creator>
<dc:creator>González Flo, Eva, 1993-</dc:creator>
<dc:creator>Macía, Javier</dc:creator>
<dc:description>Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</dc:description>
<dc:date>2021</dc:date>
<dc:type>info:eu-repo/semantics/article</dc:type>
<dc:identifier>Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</dc:identifier>
<dc:identifier>2041-1723</dc:identifier>
<dc:identifier>http://hdl.handle.net/10230/47085</dc:identifier>
<dc:identifier>http://dx.doi.org/10.1038/s41467-021-21967-x</dc:identifier>
<dc:language>eng</dc:language>
<dc:relation>Nat Commun. 2021; 12(1):1679</dc:relation>
<dc:relation>info:eu-repo/grantAgreement/ES/2PE/FIS2017-88786-R</dc:relation>
<dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
<dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
<dc:rights>© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</dc:rights>
<dc:publisher>Nature Research</dc:publisher>
</ow:Publication>
</rdf:RDF>
<?xml version="1.0" encoding="UTF-8" ?>
<metadata schemaLocation="http://www.lyncode.com/xoai http://www.lyncode.com/xsd/xoai.xsd">
<element name="dc">
<element name="contributor">
<element name="author">
<element name="none">
<field name="value">Mogas Díez, Sira</field>
<field name="value">González Flo, Eva, 1993-</field>
<field name="value">Macía, Javier</field>
</element>
</element>
</element>
<element name="date">
<element name="accessioned">
<element name="none">
<field name="value">2021-04-12T07:07:16Z</field>
</element>
</element>
<element name="available">
<element name="none">
<field name="value">2021-04-12T07:07:16Z</field>
</element>
</element>
<element name="issued">
<element name="none">
<field name="value">2021</field>
</element>
</element>
</element>
<element name="identifier">
<element name="citation">
<element name="none">
<field name="value">Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x</field>
</element>
</element>
<element name="issn">
<element name="none">
<field name="value">2041-1723</field>
</element>
</element>
<element name="uri">
<element name="none">
<field name="value">http://hdl.handle.net/10230/47085</field>
</element>
</element>
<element name="doi">
<element name="none">
<field name="value">http://dx.doi.org/10.1038/s41467-021-21967-x</field>
</element>
</element>
</element>
<element name="description">
<element name="abstract">
<element name="none">
<field name="value">Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.</field>
</element>
</element>
<element name="provenance">
<element name="en">
<field name="value">Made available in DSpace on 2021-04-12T07:07:16Z (GMT). No. of bitstreams: 1 Mogas_nc_prin.pdf: 1237407 bytes, checksum: d42106e02c64831f8b97e30595639d6f (MD5) Previous issue date: 2021</field>
</element>
</element>
<element name="sponsorship">
<element name="none">
<field name="value">Funding for this study and for the open access charge was in the form of grants from the Spanish Ministry of Economy and Competitiveness [MINECO AEI-FIS2017-88786-R and FEDER] and UPF INNOValora 2019 [INNOV19-01-1]. This work was supported by “Unidad de Excelencia María de Maeztu” and funded by the AEI (CEX2018-000792-M). E.G.F. is a recipient of an FI-DGR (2017 FI_B 00018) fellowship.</field>
</element>
</element>
</element>
<element name="format">
<element name="mimetype">
<element name="none">
<field name="value">application/pdf</field>
</element>
</element>
</element>
<element name="language">
<element name="iso">
<element name="none">
<field name="value">eng</field>
</element>
</element>
</element>
<element name="publisher">
<element name="none">
<field name="value">Nature Research</field>
</element>
</element>
<element name="relation">
<element name="ispartof">
<element name="none">
<field name="value">Nat Commun. 2021; 12(1):1679</field>
</element>
</element>
<element name="projectID">
<element name="none">
<field name="value">info:eu-repo/grantAgreement/ES/2PE/FIS2017-88786-R</field>
</element>
</element>
</element>
<element name="rights">
<element name="none">
<field name="value">© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.</field>
</element>
<element name="uri">
<element name="none">
<field name="value">http://creativecommons.org/licenses/by/4.0/</field>
</element>
</element>
<element name="accessRights">
<element name="none">
<field name="value">info:eu-repo/semantics/openAccess</field>
</element>
</element>
</element>
<element name="title">
<element name="none">
<field name="value">2D printed multicellular devices performing digital and analogue computation</field>
</element>
</element>
<element name="type">
<element name="none">
<field name="value">info:eu-repo/semantics/article</field>
</element>
<element name="version">
<element name="none">
<field name="value">info:eu-repo/semantics/publishedVersion</field>
</element>
</element>
</element>
<element name="subject">
<element name="keyword">
<element name="none">
<field name="value">Assay systems</field>
<field name="value">Synthetic biology</field>
</element>
</element>
</element>
</element>
<element name="bundles">
<element name="bundle">
<field name="name">THUMBNAIL</field>
<element name="bitstreams">
<element name="bitstream">
<field name="name">Mogas_nc_prin.pdf.jpg</field>
<field name="originalName">Mogas_nc_prin.pdf.jpg</field>
<field name="description">IM Thumbnail</field>
<field name="format">image/jpeg</field>
<field name="size">22248</field>
<field name="url">http://repositori.upf.edu/bitstream/10230/47085/3/Mogas_nc_prin.pdf.jpg</field>
<field name="checksum">91b7aea7f8fcbedac159313dcb4e6fe7</field>
<field name="checksumAlgorithm">MD5</field>
<field name="sid">3</field>
</element>
</element>
</element>
<element name="bundle">
<field name="name">TEXT</field>
<element name="bitstreams">
<element name="bitstream">
<field name="name">Mogas_nc_prin.pdf.txt</field>
<field name="originalName">Mogas_nc_prin.pdf.txt</field>
<field name="description">Extracted text</field>
<field name="format">text/plain</field>
<field name="size">49126</field>
<field name="url">http://repositori.upf.edu/bitstream/10230/47085/2/Mogas_nc_prin.pdf.txt</field>
<field name="checksum">24df4f9bd93667406a12676df4746ce2</field>
<field name="checksumAlgorithm">MD5</field>
<field name="sid">2</field>
</element>
</element>
</element>
<element name="bundle">
<field name="name">ORIGINAL</field>
<element name="bitstreams">
<element name="bitstream">
<field name="name">Mogas_nc_prin.pdf</field>
<field name="format">application/pdf</field>
<field name="size">1237407</field>
<field name="url">http://repositori.upf.edu/bitstream/10230/47085/1/Mogas_nc_prin.pdf</field>
<field name="checksum">d42106e02c64831f8b97e30595639d6f</field>
<field name="checksumAlgorithm">MD5</field>
<field name="sid">1</field>
</element>
</element>
</element>
</element>
<element name="others">
<field name="handle">10230/47085</field>
<field name="identifier">oai:repositori.upf.edu:10230/47085</field>
<field name="lastModifyDate">2021-04-13 03:30:38.974</field>
</element>
<element name="repository">
<field name="name">Repositori digital de la UPF</field>
<field name="mail">repositori@upf.edu</field>
</element>
</metadata>