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5-Dodecanolide, a Compound Isolated from Pig Lard, Presents Powerful Anti-Inflammatory Properties

Identificadores del recurso

Capo X, Martorell M, Tur JA, Sureda A, Pons A. 5-Dodecanolide, a Compound Isolated from Pig Lard, Presents Powerful Anti-Inflammatory Properties. Molecules. 2021 Dec;26(23):7363.

https://hdl.handle.net/20.500.13003/19398

10.3390/molecules26237363

1420-3049

34885945

L636870762

2-s2.0-85121131008

734538100001

Procedència

(Docusalut. Repositorio institucional del sistema sanitario público de las Islas Baleares)

Fitxa

Títol:: 5-Dodecanolide, a Compound Isolated from Pig Lard, Presents Powerful Anti-Inflammatory Properties
Tema:: Dietary Fats; Disease Models, Animal; Male; Pork Meat; Fatty Acids, Monounsaturated; Rats; Animals; Inflammation; Rats, Sprague-Dawley; Anti-Inflammatory Agents; Swine; Carne de Cerdo; Animales; Porcinos; Antiinflamatorios; Ácidos Grasos Monoinsaturados; Ratas; Ratas Sprague-Dawley; Inflamación; Grasas de la Dieta; Modelos Animales de Enfermedad; Masculino; pig lard; inflammation; 5-dodecanolide; lipid mediators
Descripció:: Background: Pork lard (PL) is traditionally used as an anti-inflammatory agent. We propose to demonstrate the anti-inflammatory properties of PL, and elucidate which compounds could be responsible for the anti-inflammatory effects. Methods: The anti-inflammatory effects of PL were tested in a rat model of zymosan-induced hind paw inflammation. Further, the hydroalcoholic extract from PL was obtained, the composition analyzed, and the anti-inflammatory activity of the extracts and isolated components assayed using immune cells stimulated with lipopolysaccharide (LPS). Results: Applying the ointment on the inflamed rat feet reduced the foot diameter, foot weight, and activities of antioxidant enzymes and inflammatory markers of circulating neutrophils. The main components of the hydroalcoholic extract were 5-dodecanolide, oleamide, hexadecanoic acid, 9-octadecenoic acid, hexadecanamide, and resolvin D1. Conclusions: PL reduces the immune response in an animal model stimulated with zymosan. Hydroalcoholic PL extract and its components (5-Dodecanolide, Oleamide, and Resolvin D1) exerted an anti-inflammatory effect on LPS-stimulated neutrophils and peripheral mononuclear cells reducing the capability to produce TNF alpha, as well as the activities of antioxidant and pro-inflammatory enzymes. These effects are attributable to 5-dodecanolide, although the effects of this compound alone do not reach the magnitude of the anti-inflammatory effects observed by the complete hydroalcoholic extract.; This research was funded by the Government of the Balearic Islands (grant number AAEE26/2017) FIS Accion Estrategica de Salud. Ministerio de Economia y Competitividad, Carlos III Health Institute (PI20/00456); and CIBEROBN (Physiopathology of Obesity and Nutrition, CB12/03/30038, Carlos III Health Institute), which is cofounded by the European Regional Development Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Idioma:: English
Autor/Productor:: Capó Fiol, Xavier; Martorell, Miquel; Tur, Josep A.; Sureda, Antoni; Pons, Antoni
Editor:: MDPI
Drets:: Attribution 4.0 International; http://creativecommons.org/licenses/by/4.0/; open access
Data:: 2023-09-26T17:55:40Z; 2021-12
Tipo de recurso:: research article
Format:: application/pdf

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2. <dc:creator>Capó Fiol, Xavier</dc:creator>
3. <dc:creator>Martorell, Miquel</dc:creator>
4. <dc:creator>Tur, Josep A.</dc:creator>
5. <dc:creator>Sureda, Antoni</dc:creator>
6. <dc:creator>Pons, Antoni</dc:creator>
7. <dc:subject>Dietary Fats</dc:subject>
8. <dc:subject>Disease Models, Animal</dc:subject>
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11. <dc:subject>Fatty Acids, Monounsaturated</dc:subject>
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13. <dc:subject>Animals</dc:subject>
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16. <dc:subject>Anti-Inflammatory Agents</dc:subject>
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26. <dc:subject>Grasas de la Dieta</dc:subject>
27. <dc:subject>Modelos Animales de Enfermedad</dc:subject>
28. <dc:subject>Masculino</dc:subject>
29. <dc:subject>pig lard</dc:subject>
30. <dc:subject>inflammation</dc:subject>
31. <dc:subject>5-dodecanolide</dc:subject>
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34. <dc:description>This research was funded by the Government of the Balearic Islands (grant number AAEE26/2017) FIS Accion Estrategica de Salud. Ministerio de Economia y Competitividad, Carlos III Health Institute (PI20/00456); and CIBEROBN (Physiopathology of Obesity and Nutrition, CB12/03/30038, Carlos III Health Institute), which is cofounded by the European Regional Development Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</dc:description>
35. <dc:date>2023-09-26T17:55:40Z</dc:date>
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37. <dc:date>2021-12</dc:date>
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  7. <dc:description>Background: Pork lard (PL) is traditionally used as an anti-inflammatory agent. We propose to demonstrate the anti-inflammatory properties of PL, and elucidate which compounds could be responsible for the anti-inflammatory effects. Methods: The anti-inflammatory effects of PL were tested in a rat model of zymosan-induced hind paw inflammation. Further, the hydroalcoholic extract from PL was obtained, the composition analyzed, and the anti-inflammatory activity of the extracts and isolated components assayed using immune cells stimulated with lipopolysaccharide (LPS). Results: Applying the ointment on the inflamed rat feet reduced the foot diameter, foot weight, and activities of antioxidant enzymes and inflammatory markers of circulating neutrophils. The main components of the hydroalcoholic extract were 5-dodecanolide, oleamide, hexadecanoic acid, 9-octadecenoic acid, hexadecanamide, and resolvin D1. Conclusions: PL reduces the immune response in an animal model stimulated with zymosan. Hydroalcoholic PL extract and its components (5-Dodecanolide, Oleamide, and Resolvin D1) exerted an anti-inflammatory effect on LPS-stimulated neutrophils and peripheral mononuclear cells reducing the capability to produce TNF alpha, as well as the activities of antioxidant and pro-inflammatory enzymes. These effects are attributable to 5-dodecanolide, although the effects of this compound alone do not reach the magnitude of the anti-inflammatory effects observed by the complete hydroalcoholic extract.</dc:description>
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  10. <dc:date>2021-12</dc:date>
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  12. <dc:identifier>Capo X, Martorell M, Tur JA, Sureda A, Pons A. 5-Dodecanolide, a Compound Isolated from Pig Lard, Presents Powerful Anti-Inflammatory Properties. Molecules. 2021 Dec;26(23):7363.</dc:identifier>
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