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β-Carotene Impacts the Liver MicroRNA Profile in a Sex-Specific Manner in Mouse Offspring of Western Diet-Fed Mothers: Results from Microarray Analysis by Direct Hybridization

Identificadores del recurso

Abrego-Guandique DM, Galmés S, García-Rodríguez A, Cannataro R, Caroleo MC, Ribot J, et al. β-Carotene Impacts the Liver MicroRNA Profile in a Sex-Specific Manner in Mouse Offspring of Western Diet-Fed Mothers: Results from Microarray Analysis by Direct Hybridization. Int J Mol Sci. 2024 Nov 30;25(23).

https://hdl.handle.net/20.500.13003/21512

10.3390/ijms252312899

1422-0067

39684610

L2032586047

2-s2.0-85212195869

001376547100001

Procedència

(Docusalut. Repositorio institucional del sistema sanitario público de las Islas Baleares)

Fitxa

Títol:: β-Carotene Impacts the Liver MicroRNA Profile in a Sex-Specific Manner in Mouse Offspring of Western Diet-Fed Mothers: Results from Microarray Analysis by Direct Hybridization
Tema:: Diet, Western; Pregnancy; Liver; Male; MicroRNAs; Sex Factors; Female; Gene Expression Profiling; beta Carotene; Animals; Prenatal Exposure Delayed Effects; Dietary Supplements; Mice; Animales; beta Caroteno; Dieta Occidental; Femenino; Hígado; Masculino; Factores Sexuales; Embarazo; Ratones; Efectos Tardíos de la Exposición Prenatal; Suplementos Dietéticos; Perfilación de la Expresión Génica; MicroARNs
Descripció:: Maternal unbalanced diets cause adverse metabolic programming and affect the offspring's liver microRNA (miRNA) profile. The liver is a site of β-carotene (BC) metabolism and a target of BC action. We studied the interaction of maternal Western diet (WD) and early-life BC supplementation on the epigenetic remodeling of offspring's liver microRNAs. Mouse offspring of WD-fed mothers were given a daily placebo (controls) or BC during suckling. Biometric parameters and liver miRNAome by microarray hybridization were analyzed in newly weaned animals. BC sex-dependently impacted the liver triacylglycerol content. The liver miRNAome was also differently affected in male and female offspring, with no overlap in differentially expressed (DE) miRNAs between sexes and more impact in females. Bioinformatic analysis of DE miRNA predicted target genes revealed enrichment in biological processes/pathways related to metabolic processes, regulation of developmental growth and circadian rhythm, liver homeostasis and metabolism, insulin resistance, and neurodegeneration, among others, with differences between sexes. Fifty-five percent of the overlapping target genes in both sexes identified were targeted by DE miRNAs changed in opposite directions in males and females. The results identify sex-dependent responses of the liver miRNA expression profile to BC supplementation during suckling and may sustain further investigations regarding the long-term impact of early postnatal life BC supplementation on top of an unbalanced maternal diet.
Idioma:: English
Relació:: https://doi.org/10.3390/ijms252312899
Autor/Productor:: Abrego-Guandique, Diana Marisol; Galmés, Sebastià; García-Rodríguez, Adrián; Cannataro, Roberto; Caroleo, Maria Cristina; Ribot, Joan; Bonet, M Luisa; Cione, Erika
Editor:: MDPI
Drets:: Atribución 4.0 Internacional; http://creativecommons.org/licenses/by/4.0/; open access
Data:: 2024-12-19T11:28:50Z; 2024-11-30
Tipo de recurso:: research article
Format:: application/pdf

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