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α-Fluoromethylhistidine influences somatostatin content, binding and inhibition of adenylyl cyclase activity in the rat frontoparietal cortex

Identificadores del recurso

Regulatory Peptides, 1995, n. 59, p. 111-120

0167-0115

http://hdl.handle.net/10017/2319

10.1016/0167-0115(95)00080-U

Procedència

(e_Buah - Biblioteca Digital de la Universidad de Alcalá)

Fitxa

Títol:: α-Fluoromethylhistidine influences somatostatin content, binding and inhibition of adenylyl cyclase activity in the rat frontoparietal cortex
Tema:: α-Fluoromethylhistidine; Somatostatin receptor; Adenylyl cyclase; Rat; Frontoparietal cortex; Bioquímica; Ciencia; Biochemistry; Science
Descripció:: Slow-wave sleep, wakefulness, locomotor activity and learning and memory are regulated in similar ways by somatostatin (SS) and histamine. To clarify the possible role of endogenous histamine on the somatostatinergic system of the rat frontoparietal cortex, we studied the effect of 50 /xg of a-fluoromethylhistidine (a-FMH), a specific inhibitor of histidine decarboxylase, administered intracerebroventricularly (i.c.v.) at 1, 4 and 6 h, on somatostatin-like immunoreactivity (SSLI) content and the SS receptor/effector system. The histamine content in the frontoparietal cortex decreased to about 67, 60 and 72% of control values at 1, 4 and 6 h after ot-FMH administration, respectively. At 6 h after a-FMH injection, there was an increase in SSLI content and a decrease in the number of SS receptors, with no change in the apparent affinity. No significant differences were seen for the basal and forskolin (FK)-stimulated adenylyl cyclase (AC) activities in the frontoparietal cortex of a-FMH-treated rats when compared to the control group at all times studied. At 6 h after a-FMH administration, however, the capacity of SS to inhibit basal and FK-stimulated AC activity in the frontoparietal cortex was significantly lower than in the control group. The ability of the stable GTP analogue 5'-guanylylimidodiphosphate (Gpp(NH)p) to inhibit FK-stimulated AC activity in frontoparietal cortex membranes was the same in the a-FMH-treated (6 h) and control animals. Therefore, the decreased SS-mediated inhibition of AC activity observed in the t~-FMI-I-treated rats is not due to an alteration at the guanine nucleotide-binding inhibitory protein (G i) level but rather may be due to the decrease in the number of SS receptors. Taken together, these data suggest that a-FMH influences the sensitivity to SS in the rat frontoparietal cortex.; This work was supported by a grant from the Direcci6n General de Investigación Cientifica y Técnica of Spain.
Idioma:: English
Relació:: http://dx.doi.org/10.1016/0167-0115(95)00080-U
Autor/Productor:: Puebla Jiménez, Lilian; Arilla Ferreiro, Eduardo
Editor:: Elsevier
Drets:: © Elsevier Science, 1995; info:eu-repo/semantics/openAccess
Data:: 2008-11-25T08:14:49Z; 1995
Tipo de recurso:: info:eu-repo/semantics/article; info:eu-repo/semantics/publishedVersion
Format:: application/pdf

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mets

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Se ha omitido la presentación del registro por ser demasiado largo. Si lo desea, puede descargárselo en el enlace anterior.

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qdc

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xoai

Descarregar XML

Se ha omitido la presentación del registro por ser demasiado largo. Si lo desea, puede descargárselo en el enlace anterior.