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3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency
Identificadores del recurso
Gracia-Marco L, Gonzalez-Salvatierra S, Garcia-Martin A, Ubago-Guisado E, Garcia-Fontana B, Gil-Cosano JJ, et al. 3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency. J Clin Med. 2021 Feb 9;10(4):657.
33572103
10.3390/jcm10040657
2077-0383
PMC7914467
Procedència
(RISalud-ANDALUCÍA)Fitxa
- Títol:
- 3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency
- Tema:
- DXA
- Bone modelling and remodelling
- Bone QCT/microCT
- Acromegaly
- Cortical bone
- Growth hormone
- Osteoporosis
- Absorciometría de fotón
- Acromegalia
- Hueso cortical
- Hormona del crecimiento
- Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
- Medical Subject Headings::Persons::Persons::Age Groups::Adult
- Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography::Absorptiometry, Photon
- Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density
- Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neck
- Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies
- Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Endocrine::Acromegaly
- Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Control Groups
- Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur
- Medical Subject Headings::Information Science::Information Science::Computing Methodologies::Software
- Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones
- Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth Hormone
- Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Metabolic::Osteoporosis
- Descripció:
- The skeleton is regulated by and responds to pituitary hormones, especially when the circulating levels are perturbed in disease. This study aims to analyse the between-group differences in 3D dual-energy X-ray absorptiometry (DXA) parameters at the hip site among patients with acromegaly or adult growth hormone deficiency (AGHD) and a healthy control group. The current cross-sectional study includes data for 67 adults, 20 with acromegaly, 14 with AGHD and 33 healthy controls. We obtained the areal bone mineral density (aBMD) outcomes using DXA and cortical and trabecular parameters using 3D-DXA software (3D-SHAPER). The mean-adjusted 3D-DXA parameters did not differ between acromegaly patients and the controls (p > 0.05); however, we found cortical bone impairment (-7.3% to -8.4%; effect size (ES) = 0.78) in AGHD patients (p < 0.05). Differences in the cortical bone parameters were more evident when comparing AGHD patients (-8.5% to -16.2%; ES = 1.22 to 1.24) with acromegaly patients (p < 0.05). In brief, the 3D mapping highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and the controls. Overall, AGHD patients displayed lower cortical parameters at the trochanter, femoral neck and intertrochanter compared to the controls and acromegaly patients. To sum up, 3D-DXA provided useful information about the characteristics of bone involvement in growth hormone (GH)-related disorders. Patients with AGHD showed distinct involvement of the cortical structure.
- Yes
- Idioma:
- Relació:
- https://www.mdpi.com/2077-0383/10/4/657/htm
- Autor/Productor:
- Gracia-Marco, Luis
- Gonzalez-Salvatierra, Sheila
- Garcia-Martin, Antonia
- Ubago-Guisado, Esther
- Garcia-Fontana, Beatriz
- Gil-Cosano, José Juan
- Muñoz-Torres, Manuel
- Editor:
- MDPI
- Otros colaboradores/productores:
- [Gracia-Marco,L; Ubago-Guisado,E; Gil-Cosano,JJ] PROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain. [Gracia-Marco,L; Ubago-Guisado,E] Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain. [Gonzalez-Salvatierra,S; Garcia-Martin,A; Garcia-Fontana,B; Muñoz-Torres,M] Bone Metabolic Unit, Endocrinology and Nutrition Division, University Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain. [Gonzalez-Salvatierra,S; Muñoz-Torres,M] Department of Medicine, University of Granada, Granada, Spain. [Garcia-Martin,A; Garcia-Fontana,B; Muñoz-Torres,M] CIBERFES, Instituto de Salud Carlos III, Madrid, Spain. [Ubago-Guisado,E] Escuela Andaluza de Salud Pública (EASP), Granada, Spain
- This research was funded by the Fondo de Investigación Sanitaria (Instituto de Salud Carlos III) with co-financing from FEDER (grant number PI18/01235), and L.G.-M. was funded by the La Caixa Foundation within the Junior Leader fellowship programme (ID 100010434; code LCF/BQ/PR19/11700007)
- Drets:
- Atribución 4.0 Internacional
- http://creativecommons.org/licenses/by/4.0/
- open access
- Data:
- 2022-09-21T07:00:44Z
- 2021-02-09
- Tipo de recurso:
- research article
- VoR
- Format:
- application/pdf