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1D to 2D Self Assembly of Cyclic Peptides

Identificadores del recurso

J. Am. Chem. Soc. 2020, 142, 1, 300-307

0002-7863

http://hdl.handle.net/10347/20679

10.1021/jacs.9b10582

1520-5126

Procedència

(Minerva. Repositorio Institucional da Universidade de Santiago de Compostela)

Fitxa

Títol:: 1D to 2D Self Assembly of Cyclic Peptides
Tema:: Self organization; Peptides and proteins; Nanotubes; Monomers; Two dimensional materials
Descripció:: Despite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes. We here report d/l-alternating cyclic peptides that undergo one-dimensional self-assembly into amphiphilic nanotubes, which subsequently arrange as tubular bilayers to form giant nanosheets in the mesoscale. Reversible transitions between the assembled, dispersed, and aggregated states of these nanosheets can be triggered by external stimuli. The characteristic flexibility, defined chemical topology, and length scale of these nanosheets set a clear distinction between this new supramolecular architecture and previously reported 2D nanostructures. The sequential 1D-to-2D self-assembly of peptides described here provides a conceptually new approach to achieve two-dimensional materials with hierarchical organization. These giant nanosheets represent one of the largest 2D supramolecular materials ever made, with potential application as long-range molecular transporters, responsive surfaces, and (bio)sensors; This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R], the Xunta de Galicia (ED431C 2017/25, 2016-AD031 and Centro Singular de Investigación de Galicia accreditation 2016-2019, ED431G/09), the ISCIII (RD16/0008/003), and the European Union (European Regional Development Fund, ERDF). I.I. thanks the European Commission for a Marie Curie fellowship (MSCA-IF-2018-843332) and the Spanish AEI for a Juan de la Cierva—Formación Fellowship (FJCI-2017-31795). J.M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786), and a Young Investigator Grant from the HFSP (RGY0066/2017). We thank Dr. Eugenio Solla, Prof. Juan Granja, Dr. Julian Bergueiro, Dr. Andreas Vargas Jentzsch, and Dr. Mark J. van Raaij for helpful discussions. We also thank Dr. Bergueiro for Figure 1 and Dr. Vargas Jentzsch for assistance with DFT calculations; SI
Idioma:: English
Relació:: https://doi.org/10.1021/jacs.9b10582; info:eu-repo/grantAgreement/EC/H2020/677786; info:eu-repo/grantAgreement/EC/H2020/843332; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89890-R/ES/PEPTIDOS HIBRIDOS PARA EL TRANSPORTE SELECTIVO Y ENTREGA DE PROTEINAS TERAPEUTICAS; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RYC-2013-13784/ES
Autor/Productor:: Insua López, Ignacio; Montenegro García, Javier
Editor:: American Chemical Society
Otros colaboradores/productores:: Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares; Universidade de Santiago de Compostela. Departamento de Química Orgánica
Drets:: Copyright © 2019 American Chemical Society; open access
Data:: 2020-02-05T11:52:38Z; 2021-01-09T02:00:09Z; 2020
Tipo de recurso:: journal article; AM

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2. <dc:creator>Insua López, Ignacio</dc:creator>
3. <dc:creator>Montenegro García, Javier</dc:creator>
4. <dc:contributor>Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares</dc:contributor>
5. <dc:contributor>Universidade de Santiago de Compostela. Departamento de Química Orgánica</dc:contributor>
6. <dc:subject>Self organization</dc:subject>
7. <dc:subject>Peptides and proteins</dc:subject>
8. <dc:subject>Nanotubes</dc:subject>
9. <dc:subject>Monomers</dc:subject>
10. <dc:subject>Two dimensional materials</dc:subject>
11. <dc:description>Despite recent developments in two-dimensional self-assembly, most supramolecular 2D materials are assembled by tedious methodologies, with complex surface chemistry and small sizes. We here report d/l-alternating cyclic peptides that undergo one-dimensional self-assembly into amphiphilic nanotubes, which subsequently arrange as tubular bilayers to form giant nanosheets in the mesoscale. Reversible transitions between the assembled, dispersed, and aggregated states of these nanosheets can be triggered by external stimuli. The characteristic flexibility, defined chemical topology, and length scale of these nanosheets set a clear distinction between this new supramolecular architecture and previously reported 2D nanostructures. The sequential 1D-to-2D self-assembly of peptides described here provides a conceptually new approach to achieve two-dimensional materials with hierarchical organization. These giant nanosheets represent one of the largest 2D supramolecular materials ever made, with potential application as long-range molecular transporters, responsive surfaces, and (bio)sensors</dc:description>
12. <dc:description>This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R], the Xunta de Galicia (ED431C 2017/25, 2016-AD031 and Centro Singular de Investigación de Galicia accreditation 2016-2019, ED431G/09), the ISCIII (RD16/0008/003), and the European Union (European Regional Development Fund, ERDF). I.I. thanks the European Commission for a Marie Curie fellowship (MSCA-IF-2018-843332) and the Spanish AEI for a Juan de la Cierva—Formación Fellowship (FJCI-2017-31795). J.M. received a Ramón y Cajal (RYC-2013-13784), an ERC Starting Investigator Grant (DYNAP-677786), and a Young Investigator Grant from the HFSP (RGY0066/2017). We thank Dr. Eugenio Solla, Prof. Juan Granja, Dr. Julian Bergueiro, Dr. Andreas Vargas Jentzsch, and Dr. Mark J. van Raaij for helpful discussions. We also thank Dr. Bergueiro for Figure 1 and Dr. Vargas Jentzsch for assistance with DFT calculations</dc:description>
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15. <dc:date>2021-01-09T02:00:09Z</dc:date>
16. <dc:date>2020</dc:date>
17. <dc:type>journal article</dc:type>
18. <dc:type>AM</dc:type>
19. <dc:identifier>J. Am. Chem. Soc. 2020, 142, 1, 300-307</dc:identifier>
20. <dc:identifier>0002-7863</dc:identifier>
21. <dc:identifier>http://hdl.handle.net/10347/20679</dc:identifier>
22. <dc:identifier>10.1021/jacs.9b10582</dc:identifier>
23. <dc:identifier>1520-5126</dc:identifier>
24. <dc:language>eng</dc:language>
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26. <dc:relation>info:eu-repo/grantAgreement/EC/H2020/677786</dc:relation>
27. <dc:relation>info:eu-repo/grantAgreement/EC/H2020/843332</dc:relation>
28. <dc:relation>info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89890-R/ES/PEPTIDOS HIBRIDOS PARA EL TRANSPORTE SELECTIVO Y ENTREGA DE PROTEINAS TERAPEUTICAS</dc:relation>
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30. <dc:rights>Copyright © 2019 American Chemical Society</dc:rights>
31. <dc:rights>open access</dc:rights>
32. <dc:publisher>American Chemical Society</dc:publisher>
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