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A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome

Identificadores del recurso

Galmés Monroig S, Cifre M, Palou Oliver A, Oliver P, Serra F. A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome. Nutrients. 2019 Feb;11(2):298.

2072-6643

http://hdl.handle.net/20.500.13003/17664

10.3390/nu11020298

30704070

L2001523709

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Procedència

(Docusalut. Repositorio institucional del sistema sanitario público de las Islas Baleares)

Fitxa

Títol:: A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome
Tema:: Metabolic Syndrome; Genetic Predisposition to Disease; Genotype; Young Adult; Adult; Gene Expression Regulation; Humans; Inflammation; Anti-Inflammatory Agents; Obesity; Male; Biomarkers; Eicosapentaenoic Acid; Docosahexaenoic Acids; Female; Risk Factors; Odds Ratio; Oportunidad Relativa; Biomarcadores; Ácido Eicosapentaenoico; Síndrome Metabólico; Ácidos Docosahexaenoicos; Predisposición Genética a la Enfermedad; Femenino; Masculino; Regulación de la Expresión Génica; Factores de Riesgo; Antiinflamatorios; Humanos; Obesidad; Adulto Joven; Inflamación; Genotipo; Adulto; genetic score; obesity; metabolic syndrome; low-grade inflammation; type 2 diabetes
Descripció:: Omega-3 rich diets have been shown to improve inflammatory status. However, in an ex vivo system of human blood cells, the efficacy of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) modulating lipid metabolism and cytokine response is attenuated in overweight subjects and shows high inter-individual variability. This suggests that obesity may be exerting a synergistic effect with genetic background disturbing the anti-inflammatory potential of omega-3 long-chain polyunsaturated fatty acids (PUFA). In the present work, a genetic score aiming to explore the risk associated to low grade inflammation and obesity (LGI-Ob) has been elaborated and assessed as a tool to contribute to discern population at risk for metabolic syndrome. Pro-inflammatory gene expression and cytokine production as a response to omega-3 were associated with LGI-Ob score; and lower anti-inflammatory effect of PUFA was observed in subjects with a high genetic score. Furthermore, overweight/obese individuals showed positive correlation of both plasma C-Reactive Protein and triglyceride/HDLc-index with LGI-Ob; and high LGI-Ob score was associated with greater hypertension (p = 0.047), Type 2 diabetes (p = 0.026), and metabolic risk (p = 0.021). The study shows that genetic variation can influence inflammation and omega-3 response, and that the LGI-Ob score could be a useful tool to classify subjects at inflammatory risk and more prone to suffer metabolic syndrome and associated metabolic disturbances.; S.G. is supported by a PhD fellowship (FPI/1680/2014) of the Conselleria d'Educacio, Cultura i Universitats, del Govern de les Illes Balears, Fondo Social Europeo de la Union Europea. M.C. has been supported by a PhD fellowship (DI-14-06569) of the Ministerio de Economia y Competitividad. This work was supported by the Spanish Government: INTERBIOBES-AGL2015-67019-P (AEI, MINECO/FEDER, EU). The Laboratory of Molecular Biology, Nutrition and Biotechnology is a member of the European Research Network of Excellence NuGO (The European Nutrigenomics Organisation, EU Contract: FOOD-CT-2004-506360 NUGO).
Idioma:: English
Relació:: https://dx.doi.org/10.3390/nu11020298
Autor/Productor:: Galmes, Sebastia; Cifre, Margalida; Palou, Andreu; Oliver, Paula; Serra, Francisca
Editor:: MDPI
Drets:: Attribution 4.0 International; http://creativecommons.org/licenses/by/4.0/; open access
Data:: 2021-08-26T07:09:53Z; 2019-02
Tipo de recurso:: research article

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50. <dc:date>2019-02</dc:date>
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