A body shape index and vascular structure and function in Spanish adults (MARK study) A cross-sectional study
Gomez-Marcos, Manuel A.
Gomez-Sanchez, Leticia
Carmen Patino-Alonso, Maria
Recio-Rodriguez, Jose I.
Gomez-Sanchez, Marta
Reigada Mendez, Rebeca
Marti, Ruth
Agudo-Conde, Cristina
Ramos, Rafel
Rodriguez-Sanchez, Emiliano
Maderuelo-Fernandez, Jose A.
Garcia-Ortiz, Luis
MARK Grp
Area Under Curve
Cardiovascular Diseases
Anthropometry
Aged
European Continental Ancestry Group
Spain
Adult
Risk Assessment
Humans
Pulse Wave Analysis
Middle Aged
Cross-Sectional Studies
Longitudinal Studies
Male
Carotid Intima-Media Thickness
Female
Risk Factors
Regression Analysis
Ultrasonography
Ankle Brachial Index
Análisis de la Onda del Pulso
Ultrasonografía
Femenino
Grupo de Ascendencia Continental Europea
Masculino
Estudios Transversales
Factores de Riesgo
Índice Tobillo Braquial
Estudios Longitudinales
Humanos
Persona de Mediana Edad
Anciano
Antropometría
Medición de Riesgo
Grosor Intima-Media Carotídeo
Enfermedades Cardiovasculares
Adulto
Análisis de Regresión
España
Área Bajo la Curva
a body shape index
brachial ankle pulse wave velocity
cardio ankle vascular index
carotid intima media thickness
intermediate cardiovascular risk
A body shape index (ABSI) has been introduced as a marker of the relationship between body composition and all-cause mortality. However, until now, the relationships between ABSI and vascular structure and function have not been evaluated. The aim of this study was to investigate the association of ABSI with vascular structure and function in Spanish adults with intermediate cardiovascular risk. This cross-sectional study analyzed the data of 2354 subjects [age, 35-74 years (median, 62.0 years [range, 56.0-67.0 years]), 61.9% men]enrolled into the MediAte Risk management (MARK) study. ABSI was calculated by using the following formula: ABSI=waist circumference (m)/[body mass index(2/3) x height (m)(1/2))]. Vascular function was assessed by measuring cardio-ankle vascular index (CAVI) with the VaSera device and brachial ankle pulse wave velocity (baPWV) by using a validated equation. Vascular structure was assessed by measuring carotid intima-media thickness (IMT) by ultrasonography. Median value of ABSI was 0.083 (range, 0.081-0.090), mean CAVI was (8.5 +/- 1.2), and median IMT was 0.727 (range, 0.672-0.799). The values of ABSI and CAVI were higher in men. After adjusting for confounders, ABSI was positively associated with CAVI, baPWV, and average mean IMT. Thus, for each unit increase in ABSI, CAVI increased by 0.16 units, baPWV by 0.25m/s, and IMT by 0.033mm. In the logistic regression analysis, the odds ratio of ABSI was>1 for high CAVI >= 9, baPWV >= 15m/s, and IMT >= 0.90mm in the overall subject group, and in the sex-and age-specific (>62 years, <= 62 years) subgroups, after adjusting for confounders. The area under the receiver-operating characteristic curve of the ABSI was 0.631 (95% confidence interval [CI], 0.608-0.654) for CAVI >= 9, and 0.617 (95% CI, 0.593-0.641) for high baPWV >= 15m/s. ABSI showed a positive association with vascular structure and function, independent of other confounders that might influenceweight and fat mass distribution in Spanish subjects at intermediate cardiovascular risk.
This work was supported by grants from the Spanish Ministry of Science and Innovation (MICINN), the Carlos III Health Institute/European Regional Development Fund (ERDF) (MICINN, ISCIII/FEDER) (Red RedIAPP RD06/0018, Research Groups: RD16/0007/0003, RD16/0007/0004, RD16/0007/0008), the Health Research Fund (PI10/01088, PI10/02077, PI10/02043; PI13/01930), and the Regional Health Management of Castile and Leon (GRS 635/A/11; GRS 906/B/14).
2021-08-26T06:55:08Z
2021-08-26T06:55:08Z
2018-11
research article
Gomez-Marcos MA, Gomez-Sanchez L, Patino-Alonso MC, Recio-Rodriguez JI, Gomez-Sanchez M, Rigo Carratala F, et al. A body shape index and vascular structure and function in Spanish adults (MARK study) A cross-sectional study. Medicine (Baltimore). 2018 Nov;97(47):e13299.
0025-7974
http://hdl.handle.net/20.500.13003/17274
10.1097/MD.0000000000013299
1536-5964
30461641
L627391415
2-s2.0-85056803177
000452464700042
eng
https://dx.doi.org/10.1097/MD.0000000000013299
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
open access
Lippincott Williams &Wilkins